摘要
目的比较米非司酮配伍米索前列醇与羊膜腔内依沙吖啶注射终止16～24周妊娠的临床效果，为制定米非司酮配伍米索前列醇终止16-24周妊娠的用药常规提供临床依据。方法根据计算机产生的随机数字表，将629例随机分配为米非司酮配伍米索前列醇组（米非米索组，310例）和羊膜腔内依沙吖啶注射组（依沙吖啶组，319例）。两组均于胎儿、胎盘娩出后24h常规行B超检查后清宫。结果两组引产成功率分别为93．2％（289／3lO）和95．6％（305／319），差异无统计学意义（P〉0．05）。米非米索组胎儿娩出的时间为（12．0±5．9）h，显著短于依沙吖啶组的（45．2±14．1）h（P〈0．001）。米非米索组引产后24h内出血量为（113．5±69．5）mL，显著少于依沙吖啶组的（146．0±70．5）mL（P〈0．05）。结论米非司酮配伍米索前列醇终止16～24周妊娠安全、有效。
Objective To compare the clinical efficacies of mifepristone combined with misoprostol with ethacridine in terminating 16- 24 weeks gestation, so as to provide clinical evidence for routine use of mifepristone plus misoprostol for termination of 16-24 weeks of gestation. Methods A total of 629 healthy pregnant women requiring induced abortion in 16- 24 weeks gestation were randomly divided into mifepristone group （mifepristone 200 mg po, misopmstol 400 μg PV） and ethacridine group （intra-amniotic injection of ethacridine 100 mg）. The patients in both groups received routine B- ultrasound examination and curettage 24 hours after delivery. Results The success rate of labor induction were 93.2% and 95.6% in the two groups, with no significant difference between two groups （P〉0.05）. There was significant difference in the induction time between the two groups （mifepristone group E12.0±5.9] h, ethacridine group E45.2 ± 14. 1] h, P〈0.001）. The blood loss in mifepristone group was （113.5±69.5） mL, which was significantly less than that in the ethacridine group within 24 hours after induction （E146.0±70.5] mL, P〈0.05）. Conclusion Mifepristone combined with misoprostol is a safe and effective method for terminating 16-24 weeks gestation. （Shanghai Med J, 2011, 34= 390-393）
出处
《上海医学》
CAS
CSCD
北大核心
2011年第5期390-393,共4页
Shanghai Medical Journal
