摘要
目的比较米非司酮联合米索前列醇与单用米索前列醇在过期流产清宫术中的疗效。方法选自浙江省湖州市计划生育站2010年4月至2011年8月间收治的胚胎停止发育患者70例,随机分为研究组(38例)和对照组(32例)。研究组给予口服米非司酮50 mg,每12 h一次,共服3次,第3天清宫术前2 h口服米索前列醇600μg,后行清宫术;对照组术前2 h给予米索前列醇600μg,后行清宫术。结果研究组完全流产36例,不全流产2例,无流产失败;对照组完全流产29例,不全流产2例,流产失败1例。两组的完全流产率比较无显著差异(P>0.05)。研究组术后持续阴道出血时间短于对照组(x^2=4.12,P<0.05);术后阴道的出血量少于对照组(x^2=5.30,P<0.05);不良反应的发生率低于对照组(x^2=5.61,P<0.05)。结论米非司酮联合米索前列醇后行清宫术与单独应用米索前列醇清宫对过期流产的疗效相当,但联合给药能够有效减少阴道的出血时间及出血量,且发生不良反应较少。
Objective To study the clinical effect of mifepristone combined with misoprostol and misoprostol in missed abor- tion curettage. Methods Seventy cases from April 2010 to August 2011 of medical termination of pregnancy in Huzhou family plan- ning service station of Zhejiang Province were collected. All cases were divided randomly into research group （38 cases） and the con- trol group （32 cases）, The patients in research group were treated with mifepristone 50 mg once per 12 h ,3 times, on 3rd day, 600 i^g misoprostol 2 h before abortion curettage; the patients in control group were treated with 600 μg misoprostol 2 h before abortion cu- rettage. Results There was no significant difference between the 2 groups in complete abortion rate （P 〉 0.05 ）. Vaginal bleeding time in research group was significantly less than that in control group, there was significant difference between 2 groups, with X2 = 4.12 and P 〈 0.05. Blood volume in research group was significantly less than in control group, there was significant difference between the 2 groups, with X2 = 5, 30,and P 〈 0.05. The incidence of side effects of research group was significantly less than that of control group,there was significant difference between 2 groups, with X2 = 5.61 and P 〈 0.05. Conclusion Mifepristone combined with miso- prostol and misoprostol only for pregnancy termination had the same clinical effect. But mifepristone combined with misoprostol could effectively reduce the vazinal bleedinz time and blood loss. and have fewer side effects.
出处
《药学实践杂志》
CAS
2014年第1期65-67,共3页
Journal of Pharmaceutical Practice
关键词
米非司酮
米索前列醇
流产
疗效
mifepristone
misoprostol
missed abortion
clinical effect
