摘要
水体富营养化现象日益严重及藻类水华的频繁暴发已成为全球广泛关注的环境问题。而微囊藻毒素(Microcystin,MCs)是在蓝藻水华污染中出现频率最高、造成危害最严重的一种环七肽肝毒素。目前,蓝藻水华的研究主要集中在MCs对水产动物及哺乳动物造成的伤害。大量研究表明,作为肝毒素的MCs具有稳定性,不但能够在生物链中积累,而且能够诱导细胞凋亡,造成氧化应激反应,甚至可直接损伤遗传物质DNA。因此该文就MCs引起的毒理学效应(包括肝、肾毒性,诱导细胞凋亡,调控相关基因的转录,影响相关蛋白的表达及免疫系统的影响)进行了综述。
The outbreak of algal blooms has become a widespread concern in recent years.Microcystin（MC） is monocyclic heptapeptides,which is one type of algae toxins produced by cyanobacteria bloom,.and it occurs with the highest frequency and causes the most damage as well.Recent studies indicated that MCs could may induce cell apoptosis and produce oxidative stress response.This article summarized the toxicological effects induced by microcystins,including liver and kidney of microcystin toxicity,induction of apoptosis,regulation of transcription-related genes affect the expression of related proteins and the immune system and so on.
出处
《环境与健康杂志》
CAS
CSCD
北大核心
2011年第6期553-556,共4页
Journal of Environment and Health
基金
上海市教育委员会科研创新项目(09YZ277)
上海市青年科技启明星计划项目(08QA1405900)
美国国际发展署AquaFish CRSP资助项目
