摘要
目的 探讨血清神经原特异性烯醇酶（ＮＳＥ） 和胃泌素用于肺癌的临床价值。方法 采用ＡＢＣ－ ＥＬＩＳＡ 和放免法检测３０ 例正常对照、２５ 例良性肺疾病、５５ 例非小细胞肺癌（ＮＳＣＬＣ） 和１５ 例小细胞肺癌（ＳＣＬＣ） 血清ＮＳＥ和胃泌素浓度。结果 血清ＮＳＥ和胃泌素浓度在４ 组间有显著性差异（ Ｐ＜ ０－００１） 。ＮＳＥ 诊断ＳＣＬＣ 的敏感性、特异性和准确性是８０ 、８８ 和８６ ％ ；胃泌素诊断ＮＳＣＬＣ分别是６９ 、６５ 和６０ ％ 。治疗后，ＳＣＬＣ 组血清ＮＳＥ 和胃泌素均显著下降（ Ｐ＜ ０－００１） ，而ＮＳＣＬＣ组仅有胃泌素降低（ Ｐ＜ ０－００１） 。结论 ＮＳＥ 主要用于ＳＣＬＣ 的辅助诊断、术前组织学分型及疗效监测，而胃泌素用于ＮＳＣＬＣ。
Objective To study the clinical value of measurement of serum neuron specific enolase (NSE) and gastrin for lung cancer.Methods serum NSE and gastrin were measured with ABC ELISA and Radioimmunoassay in 30 healthy subjects(C),25 patients with benign pulmonary diseases (BPD),55 patients with non small cell lung cancer (NSCLC) and 15 patients with small cell lung cancer (SCLC).Reaults The serum concentrations of NSE and gastrin had significant difference in the four groups ( P <0 001).The sensitivity,specificity and accuracy of NSE for SCLC were 80,88 and 86%,gastrin for NSCLC were 69,65 and 60%,respectively.After the patients with lung cancer were treated,serum levels of NSE and gastrin were significantly decreased in SCLC ( P <0 001),but levels of gastrin were decreased in NSCLC only ( P <0 001).Conclusion NSE should be used in adjuvant diagnosing,preoperative histological typing and therapy monitoring for SCLC,and gastrin for NSCLC.
出处
《肿瘤防治研究》
CAS
CSCD
北大核心
1999年第5期339-341,共3页
Cancer Research on Prevention and Treatment
基金
贵州省卫生厅基金
