摘要
目的运用软骨延迟增强核磁成像法检测Ⅱ期、Ⅲ期股骨头坏死的软骨改变，研究股骨头坏死塌陷前后软骨的改变规律。方法采用软骨延迟增强核磁成像技术，对每名受试者进行钆增强延迟核磁共振扫描，应用MATLAB和Mrimapper软件进行数据处理，分别获得股骨头软骨感兴趣区的T1Gd数据。样本为成人激素性股骨头坏死国际骨坏死与循环协会（ARCO）分期Ⅱ期、Ⅲ期患者和健康志愿者，分为3组，A组：ARCOⅡ期，11髋；B组：ARCOⅢ期，13髋；C组：健康对照组为无髋关节疾病的健康正常成年人，10髋。结果A组T1Gd值为420±60，B组T1Gd值为361±54，C组T1Gd值为538±26，A组、B组患者T1Gd值与C组相比差异均有统计学意义（均P〈0．01）。股骨头坏死塌陷后期T1Gd值较塌陷前T1Gd值低14％，差异有统计学意义（P〈0．01）。结论股骨头坏死塌陷前的ARCOⅡ期股骨头关节软骨已经发生代谢变化，塌陷后ARCOⅡ期更加明显，说明骨坏死塌陷前期即影响关节关节软骨的代谢功能，并随坏死程度的加重而加重。
Objective To detect the cartilage changes of hip joint with osteonecrosis of femoral head （ONFH） in stages Ⅱ and Ⅲ and provide evidence for understanding cartilage changes of femoral head of osteonecrosis before collapse. Methods The cartilage changes of ONFH were determined by delayed gadolinium enhanced magnetic resonance imaging of cartilage （dGEMRIC） . According to ARCO classification of ONFH, the samples were divided into three groups ： Group A, 11 hips, stage Ⅱ ; Group B, 13 hips, stage Ⅲ; Group C, 10 hips, normal. All participates underwent the tests by dGEMRIC. And the data of T1Gd were collected and analyzed. Results The values of T1Gd were 420±60 （Group A） ,361±54 （Group B） and 538±26 （Group C） respectively. There was a significant difference among three groups. The values of T1Gd in the ONFH patients were lower than their healthy counterparts. The values of TIGd of Group B was 14% lower than those of Group A. And the difference was significant statistically. Conclusion Cartilage of the femoral head undergoes abnormal metabolic changes before collapse. There is a loss of GAG in the cartilage and it aggravates with the worsening of ONFH.
出处
《中华医学杂志》
CAS
CSCD
北大核心
2011年第21期1467-1470,共4页
National Medical Journal of China
基金
首都医学发展科研基金（2007-3014）
关键词
股骨头坏死
软骨
关节
磁共振成像
Femoral head necrosis
Cartilage, articular
Magnetic resonance imaging
