摘要
吗啡是临床上常用的一种阿片类镇痛药物,广泛用于治疗各种类型疼痛,但是长期应用吗啡会造成吗啡耐受,从而限制了吗啡的临床应用。吗啡耐受的机制十分复杂,近年来的研究表明下行疼痛易化系统参与了吗啡耐受,本文拟对近年来此方面的研究进行综述。
Morphine is a most important powerful opioid analgesic that has been widely used to alleviate various types of pain, but chronic use of morphine is accompanied by the development of morphine tolerance, which is one of the major problems associated with morphine treatment, thus limiting the clinical application of morphine, the mechanisms underlying this phenomenon are very complex and remain largely unknown, recent studies have demonstrated the participation of descending pain facilitation system in the development of morphine tolerance. In this paper,recent progress in this field is reviewed, in order to provide some new approaches for therapy of morphine tolerance.
出处
《现代生物医学进展》
CAS
2011年第13期2572-2574,共3页
Progress in Modern Biomedicine
