摘要
目的:检测妊娠高血压患者外周血中促Th2的分子IL-4、IL-2与IL-10的水平,探讨IL-2/IL-10在妊高症中的临床意义。方法:选择40例未妊娠妇女为对照组,30例正常妊娠妇女为妊娠组,28例妊娠高血压患者为妊娠高血压组,ELISA检测血清中IL-4、IL-2和IL-10的水平。结果:与对照组外周血中IL-4水平(0.53±0.04)pg/ml相比:正常妊娠组IL-4水平升高至(0.91±0.03)pg/ml(P<0.05),妊娠高血压组IL-4水平(0.67±0.35)pg/ml升高但明显低于正常妊娠组(P<0.01)。与对照组外周血中IL-2水平(0.41±0.05)pg/ml相比:正常妊娠组IL-2水平升高至(0.82±0.11)pg/ml(P<0.01);妊娠高血压组IL-2水平高达1.57±0.22(pg/ml)明显高于其它两组(P<0.01)。妊娠高血压组外周血中IL-10水平明显低于正常妊娠组IL-10水平(P<0.01);妊娠高血压组外周血中IL-2/IL-10比值明显高于于对照组及正常妊娠组的比值。结论:妊娠高血压患者外周血中细胞因子IL-2和IL-10分泌异常且诱导Th2细胞产生的IL-4降低,打破Th1/Th2平衡,致使Th1型免疫反应增强,使早孕期滋养细胞受到免疫损伤以致侵入能力下降,导致妊娠期高血压疾病的发生。
Objective： To detect the levels of IL-4 and IL-2 and IL-10 in the patients with pregnancy-induced hypertension, and discuss the detection of IL-2/IL-10. Methods： Taking 40 cases of non-pregnant women as control group, 30 normal pregnant women as pregnancy group, 28 cases of pregnancy induced hypertension as pregnancy-induced hypertension group patients, we used ELISA to detect the levels of IL-4, IL-2 and IL-10 in their serum. Results： The levels of IL-4 in peripheral blood of pregnancy group was （0.91± 0.03） pg / ml, significantly higher than the level of IL-4 （0.53 ± 0.04） pg / ml in control group （P〈0.05）. The levels of IL-4 in peripheral blood of pregnancy-induced hypertension group was （0.67± 0.35） pg / ml, significantly lower than the IL-4 level in normal pregnancy group （P〈0.01）. IL-2 levels of （0.82±0.11） pg / ml in normal pregnancy group was higher than those of （0.41±0.05） pg / ml in control group; IL-2 levels of pregnancy-induced hypertension group was 1.57 ± 0.22 （pg / ml）, significantly higher than that in the control group and normal pregnancy group （P 〈0.01）. IL-10 in peripheral blood during pregnancy was significantly higher. IL-10 levels of pregnancy-induced hypertension was significantly lower than that in normal pregnancy group （P 〈0.01）; the IL-2/IL-10 ratio in pregnancy-induced hypertension group was significantly higher than that in the control group and the normal pregnancy group. Conclusion： IL-2 and IL-10 secretion were abnormal in pregnancy-induced hypertension in patients, and the IL-4 level which could induced the produce of Th2 cells was decreased, then the Th1/Th2 balance was break, making the Thl-type immune response increased, but the invasive capacity decroased of the first trimester trophoblast cells which was injured by immune response, finally resulting in the occurrence of pregnancy induced hypertension.
出处
《现代生物医学进展》
CAS
2011年第13期2525-2527,2531,共4页
Progress in Modern Biomedicine
关键词
妊娠高血压
白介素4
白介素2
白介素10
Pregnancy-induced hypertension
Interleukin-4
Interleukin-2
Interleukin-10
