摘要
目的观察初诊2型糖尿病患者体内氧化应激改变，分析氧化应激改变与胰岛素抵抗和胰岛β细胞功能下降的关系。方法测定60例初诊2型糖尿病患者和50名正常对照者血清活性氧活力（ROS）、丙二醛（MDA）、谷胱甘肽（GSH）、超氧化物歧化酶（SOD），同时测定T2DM患者空腹胰岛素水平，采用稳态模型测定胰岛素抵抗指数（HOMA-IR）和胰岛B细胞功能（HOMA-β），比较氧化应激指标与胰岛素抵抗、胰岛B细胞功能的相关性。结果T2DM组与对照组相比，ROS显著增强，MDA明显增高，GSH、SOD明显降低。ROS、MDA与HOMA-IR呈正相关，与HOMA-β呈负相关。GSH、SOD与HoMA-IR呈负相关，与HOMA-β呈正相关。结论T2DM患者体内氧化应激明显增强．氧化应激增强．与T2DM患者胰岛素抵抗和胰岛B细胞功能下降密切相关．
Objective To investigate newly diagnosed type 2 diabetic patients＂ changes in oxidative stress in vivo, analysis of changes in oxidative stress and insulin resistance and pancreatic β-cell function decline in the relationship. Methods 60 cases of newly diagnosed type 2 diabetic patients and 50 normal controls vitality serum reactive oxygen species（ROS）, malondialdehyde（MDA）, glutathione（GSH）, superoxide dismutase（SOD） were examined, and simultaneously determinated fasting insulin levels of T2DM patients. Insulin resistance index HOMA-IR and HOMA-β were measured with homeostasis model. Indicators of oxidative stress compared with the insulin resistance and islet [3-cell function. Results Compared with control group, T2DM group＇s ROS, MDA was significantly increased, GSH, SOD significantly decreased. ROS, MDA was positively correlatedwith HOMA-IR and negatively correlated with HOMA-β. GSH, SOD was positively correlated with HOMA-β and negatively correlated with HOMA- IR. Conclusion In T2DM patients oxidative stress was increased. Enhanced oxidative stress are closely related to insulin resistance and decreased β- cell function in patients with T2DM.
作者
杨吉锋
陶松桔
张亚萍
惠辉
伍蔚凌
YANG Ji-feng, TAO Song-ju, ZHANG Ya-ping, HUI Hni, WU Wei-ling （1. Chenzhou City Jiahe Country People＇s Hospital in Hunan Province, Jiahe 424500; 2.Department of Endocrinology Diabetes, the first People＇s Hospital of Chenzhou City, Chenzhou 423000, China）
出处
《医学信息》
2011年第11期3343-3345,共3页
Journal of Medical Information
