摘要
目的观察阿托伐他汀钙在治疗颈动脉粥样硬化中对斑块面积及中膜厚度的影响。方法选取揭东县人民医院自2008年10月-2010年12月收治的颈动脉粥样硬化患者126例为研究对象,随机分为观察组(阿托伐他汀钙治疗组)和对照组(常规治疗组)各63例,治疗周期为12周,彩色B超观察两组的颈动脉斑块面积及中膜厚度变化。结果观察组与对照组经过12周治疗后颈动脉内中膜厚度(IMT)无明显变化(P>0.05),但治疗组斑块面积与治疗前及与对照组比较差异有统计学意义(P<0.05);治疗前后观察组TC、TG、hs-CRP水平差异均有统计学意义(P<0.05),对照组TG水平也有明显差异(P<0.05);治疗后CH、hs-CRP水平两组差异有统计学意义(P<0.05)。结论阿托伐他汀钙治疗颈动脉粥样硬化具有改善血脂、稳定斑块的作用,值得临床推广使用。
Objective To observe the effect of Atorvastatin calcium in treating carotid atherosclerosis and its clinical efficacy.Methods One hundred and twenty six patients with carotid atherosclerosis in our hospital from October,2008 to December,2010 were randomly divided into two groups（Atorvastatin calcium treating group,63 cases） and control group（conventional treatment group,63 cases）,A treatment cycle of 12 weeks was carried out and the plaque area intima-media thickness（IMT） were observed by Color Doppler.Results After 12 weeks of treatment,the difference in carotid IMT was not significantly between the two groups（P0.05）,but significantly in the plaque area as compared the treating group with the control group or pro-treatment（P0.05）.In treating group,there were significant differences in TC,TG,hs-CRP levels before and after the treatment（P0.05）,and the changes of TG levels was also significantly in control group（P0.05）;CH,hs-CRP levels showed a significantly different after the treatment in both groups（P0.05）.Conclusion Atorvastatin calcium can improve the blood lipid level and reverse carotid atherosclerosis plaque.
出处
《中华全科医学》
2011年第7期1078-1079,共2页
Chinese Journal of General Practice
关键词
阿托伐他汀钙
颈动脉硬化
血脂
Atorvastatin calcium
Carotid atherosclerosis
Blood lipid
