摘要
目的 评价酞胺哌啶酮对实验门脉高压大鼠的治疗作用及和肿瘤坏死因子的关系。方法 采用门脉缩窄门脉高压鼠模型(PVL)。PVL鼠从术后当天到术后2 周分别口服酞胺哌啶酮和水,于术后2 周时测定血流动力学改变和血浆肿瘤坏死因子(TNF)水平,并与对照组鼠进行比较。结果 酞胺哌啶酮能明显增加PVL鼠的平均动脉压,降低其门脉压力和血浆TNF水平。结论 酞胺哌啶酮通过降低TNF水平,改善门脉高压高动力循环状态。
Objective To study the hemodynamic effects of thalidomide on experimental portal hypertension rats and its relation with tumor necrosis factor (TNF).Methods Portal hypertensive rats induced by partial ligation of the portal vein (PVL) were divided into two groups (PVL T and PVL W) and the control rats (SHAM) without PVL were also divided into two groups (SHAM T and SHAM W).T denoted thalidomide, the rats received thalidomide from the start of the operation to 14th day after operation; W denoted water, rats received water only without thalidomide.Hemodynamic studies including mean arterial pressure (MAP), heart rate (HR) and portal pressure (PP)were performed and TNF plasma levels were assayed by cytotoxin from cell line L929 with ELISA on the 14 th day after operation.Results Thalidomide treatment induced a significant increase in mean arterial pressure and a significant decrease in portal pressure. Plasma TNF levels were lowered in thalidomide treated rats.Conclusion Thalidomide ameliorates the hemodynamic circulation of PVL rats and reduces portal pressure in portal hypertension rats.The effect of thalidomide might be explained by the reduction of TNF level.
关键词
门脉高压症
酞胺哌啶酮
血流动力学
大鼠
thalidomide
tumor necrosis factor
hypertension,portal
hemodynamic
rats
