摘要
氧化应激可引起心血管机能低下,谷胱苷肽S-转移酶(GSTs)家族在机体对抗氧化应激危害方面扮演重要角色。编码谷胱苷肽S-转移酶P1(GSTP1)的GSTP1基因具有Ile105Val多态性,该多态可明显改变GSTP1对底物的亲和力,在流行病学中被广为研究。然而,GSTP1基因与反映心血管机能的心率和血压间关系的研究少见报道。本研究选取197名正常汉族成年男性,就GSTP1基因Ile105Val多态性与心率和血压间的关系做一探索。结果检测到Ile105/Ile105和Ile105/Val105两种基因型,频率分别为78%和22%。安静心率、最大心率和心率储备在两种基因型组间都不存在显著性差异(P>0.05)。收缩压、舒张压和脉压在两种基因型组间也不存在显著性差异(P>0.05)。因此,GSTP1基因Ile105Val多态性可能对正常人体的心率和血压不产生影响。
Oxidative stress may reduce cardiovascular function.Glutathione S-transferases（GSTs） play an important role in cell defending against oxidative stress.Glutathione S-transferase P1（GSTP1） gene is one of the most intensively investigated glutathione S-transferase genes in epidemiologic studies.The GSTP1 gene displays a polymorphism at codon 105（Ile105Val）,which results in an enzyme with altered substrate affinity.To date,there have been few studies evaluating whether Ile105Val polymorphism of GSTP1 gene has an effect on cardiovascular function in the broad masses of people.In this study,we investigated the relationship between Ile105Val polymorphism of GSTP1 gene and heart rate and blood pressure in 197 unrelated adult males of Han nationality.It was found that there were two types of the GSTP1 genotypes,Ile105/Ile105 and Ile105/Val105,but genotype Val105/Val105 was not found,and the frequencies of Ile105/Ile105 and Ile105/Val105 genotypes were 78% and 22% respectively.Comparison with individuals with Ile105/Val105 genotype showed that those with Ile105/Ile105 genotype had higher rest heart rate and maximal heart rate mean values.However,whether for rest heart rate and maximal heart rate or for heart rate reserve,no significant differences were found between the two genotype groups（P0.05）.Compared with individuals with Ile105/Val105 genotype,those with Ile105/Ile105 genotype had higher systolic blood pressure and pulse pressure mean values and lower diastolic blood pressure mean value.However,for systolic blood pressure,diastolic blood pressure and pulse pressure,no significant differences were found between the two genotype groups（P0.05）.The results suggested that Ile105Val polymorphism of GSTP1 gene may not be associated with heart rate and blood pressure in the broad masses of people.
出处
《生物医学工程学杂志》
EI
CAS
CSCD
北大核心
2011年第3期543-546,共4页
Journal of Biomedical Engineering
基金
广州市体育科学研究所资助课题
关键词
谷胱苷肽S-转移酶P1
基因多态性
心率
血压
Glutathione S-transferase P1（GSTP1）
Genic polymorphism
Heart rate
Blood pressure
