摘要
目的观察银丹心脑通软胶囊治疗腔隙性脑梗死的临床疗效。方法将烟台市烟台山医院神经内科自2009年7月至2010年9月收治入院的58例腔隙性脑梗死患者按随机数字表法分为治疗组（30例1和对照组（28例）。对照组进行常规治疗，治疗组在常规治疗的基础上加用银丹心脑通软胶囊（每日3次，每次4粒，持续4周）。检测治疗前后两组患者血液流变学指标、纤维蛋白原水平．并对患者神经功能缺损程度进行评分，最后对两组患者的总体疗效进行评价。结果与治疗前相比。治疗后两组患者血液流变学指标、纤维蛋白原水平以及神经功能缺损评分明显降低，且治疗组效果优于对照组，差异有统计学意义（P〈0．05）。秩和检验结果表明治疗组与对照组疗效差异有统计学意义（P〈0．05），从平均秩次判断，治疗组疗效优于对照组。结论银丹心脑通软胶囊能下调血液中纤维蛋白原水平，明显改善腔隙性脑梗死患者的神经功能缺损症状及其血液流变学指标，对腔隙性脑梗死的治疗安全有效。
Objective To observe the clinical therapeutic effect of Yindanxinnaotong capsule on patients with lacunar infarction. Methods Fifty-eight patients with lacunar infarction, admitted to our hospital from July 2009 to September 2010, were randomly divided into control group （n=28） and Yindanxinnaotong capsule treatment group （n=30）. The patients in the control group were treated with conventional therapy and those in the treatment group were treated by combination of Yindanxinnaotong capsule （3 times daily, 4 capsules timely for a consecutive 4 weeks） with conventional method. The hemorrheological indexes, fibrinogen level and scores of neurological impairment were inspected before and after the treatment, respectively. The overall effect was evaluated. Results The hemorrheological indexes, fibrinogen level and scores of neurological impairment in the treatment group were decreased significantly as compared with those in the control group （P〈0.05）. The overall effect of the treatment group was better than that of control group. Rank sum test indicated that the treatment efficacy between treatment group and control group was significantly different （P〈0.05）; mean rank order indicated that the improvement of the treatment group was better than that of control group. Conclusion Yindanxinnaotong capsule can decrease the fibrinogen level, improve the hemorrheological indexes and neurological impairment of patients with lacunar infarction; it has definite curative effect on lacunar infarction.
出处
《中华神经医学杂志》
CAS
CSCD
北大核心
2011年第6期626-629,共4页
Chinese Journal of Neuromedicine
