摘要
目的探讨孟鲁司特治疗难治性哮喘的临床疗效。方法选择2009年10月至2010年6月收治的难治性哮喘患者78例,随机将患者分为研究组和对照组。2组均有常规治疗(激素和β2受体激动剂),治疗组在基础上加用孟鲁司特片,每晚10mg口服,2周为一个疗程,观察比较两组疗效及相关指标。结果与对照组相比,研究组的显效率、总有效率和FEV1/FVC%值占估计值的百分比均明显提高,差异均有统计学意义(P<0.05)。结论孟鲁司特在治疗难治性哮喘的过程中表现出较好的临床疗效,且副作用小,是难治性哮喘患者的药物添加治疗首选。
Objective To evaluate of the efficacy and safety of adjunctive Montelukast in children with difficult asthma.Methods 78 patients with difficult asthma were randomly divided into two groups.Both groups were given basement therapy,experimental group was added with treatment of Montelukast.10 mg every night.2 weeks as a course.The clinical efficacy was evaluated by clinical improvement seven days after the treatment.Results The total effective rate and cure rate in experimental group were significantly better than that in control group（P 0.05）.Conclusion Adjunctive Montelukast used for treatment of children with difficult asthma can significantly enhance clinical effect and reduce complications,so it deserved application and promotion in clinical work.
出处
《中国实用医药》
2011年第15期16-17,共2页
China Practical Medicine
