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糖皮质激素吸入与小剂量多索茶碱联合治疗老年哮喘的研究 被引量:10

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摘要 目的观察在吸入糖皮质激素的基础上联合小剂堪多索茶碱对轻中度老年哮喘患者的治疗作用。方法将160例轻中度老年哮喘患者随机分为三组:吸入布地奈德气雾剂+口服多索茶碱(A组),吸入布地奈德气雾剂+口服硫酸特和他林(B组),单纯吸入布地奈德气雾剂(C组)。比较各组患者临床症状及治疗前和每治疗2周后第1秒钟用力呼气容积(FEV1)的改善情况。结果三组患者的哮喘症状和肺功能在治疗后均有改善,A组临床控制率和显效率分别为18.8%和50.0%,B组分别为17.5%和52.5%,C组分别为5.0%和30.0%,A组、B组与C组比较,差异均有统计学意义(P〈0.05)。三组间FEV1改善情况虽然差异无统计学意义,但A组和B组的改善程度要比C组高。三组均未发现严重的药物不良反应。结论联合用药是治疗轻中度老年哮喘首选方式,在吸入糖皮质激素基础上联合小剂量多索茶碱是有效的治疗方法。
出处 《中国医师进修杂志(内科版)》 2007年第10期56-57,共2页 Chinese Journal of Postgraduates of Medicine
基金 江西省卫生厅科技计划项目(H20043087)
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