摘要
目的:通过对消瘀膏与其改良剂型消瘀贴体外透皮实验的比较,证实改良剂型的科学性、可行性。方法:以大黄素作为透皮率的测定指标,采用HPLC定量,用改良的Franz扩散池以及离体兔皮方法进行体外透皮实验。结果:消瘀膏中大黄素累计透皮率与时间的关系为威布尔分布模型,消瘀贴中大黄素累计透皮率与时间的关系为Density方程模型。以大黄素为指标,消瘀贴的体外透皮速率是消瘀膏的1.93倍,透皮总量是消瘀膏的2.84倍。同时测定的皮肤储量显示,消瘀贴中的大黄素在皮肤中的储量是软膏剂的3.95倍。结论:消瘀贴的透皮速率要比消瘀膏的快,透皮总量多,而且皮肤储量多于软膏剂,透皮特性明显优于原来剂型。
Objective： Through the comparison of Xiaoyu ointment and xiaoyu plaster by in vitro transdermal demonstrate,to demonstrate the scientificity and feasibility of reformed formulation.Method： The improved Franz diffusion cells and in vitro rabbit skin were used in vitro penetration experiment with emodin as an indicator of penetration rate quantitated by HPLC.Result： The cumulative penetration rate of emodin in Xiaoyu ointment fit the model of Weibull distribution,while the cumulative penetration rate of emodin in Xiaoyu plaster fit the model of Density equation.Take emodin as an index,the transdermal rate in Xiaoyu plaster was 1.93 times as Xiaoyu ointment,and the total penetrated amount was 2.84 times as Xiaoyu ointment.The results showed that the emodin of xiaoyu plaster reserved in the skin were 3.95 times more than the ointment.Conclusion： The penetration rate,total penetrated amount and the reserves in the skin of Xiaoyu plaster were better than the ointment,and the transdermal dosage form was better than the original form.
出处
《中国中药杂志》
CAS
CSCD
北大核心
2011年第12期1599-1602,共4页
China Journal of Chinese Materia Medica
基金
深圳市福田区科技局科研基金项目(FTWS084)
