摘要
脑深部电刺激(DBS)的出现,被认为是继左旋多巴后,帕金森病(PD)治疗的第二个里程碑。其能持续改善震颤、僵硬、运动减少及异动等症状,不良反应较少。立体定向毁损术是DBS应用前最常用的PD外科手术,对适应证把握和定位准确性要求高。患者选择是DBS治疗取得良好疗效的前提,治疗时间窗也非常关键。我国PD治疗的DBS发展尚受一定限制。
Deep brain stimulation （DBS） is considered as the second milestone in the treatment of Parkinson＇s disease （PD） following levodopa. DBS can improve tremor, muscle rigidity, hypokinesia and dyskinesias continually, and is of less adverse reactions. Stereotaxic surgery is the most common surgery of PD before DBS. However, it needs high requirements in grasping indication and positioning. The premise of efficacy for DBS is patient selection, and therapeutic time window is very important. The development of DBS is still subject to certain restrictions in our country.
出处
《世界临床药物》
CAS
2011年第6期329-332,共4页
World Clinical Drug
基金
上海市科学技术委员会重大科技攻关专项(10411954400)
