摘要
目的:研究早期肠内营养(EEN)对休克病人内毒素和肿瘤坏死因子-α(TNF-α)的影响及对多器官功能障碍综合征(MODS)的治疗作用。方法:将146例休克后病人分为EEN组和肠外营养(TPN)组,检测两组病人营养支持治疗前和治疗后第1、3、5天血浆中内毒素和TNF-α水平变化。统计两组病人28 d的MODS患病率和病死率。结果:EEN组休克病人第5天后血浆内毒素和TNF-α明显低于TPN组(P<0.01)。两组间MODS的患病率无显著性差异。EEN组病人MODS的病死率显著低于对照组(P<0.05)。结论:EEN可显著降低休克后病人血浆内毒素和TNF-α水平,降低了MODS的病死率。
Objective： To study the therapeutic effects of early enteral nutrition on the serum endotoxin and tumor necrosis fator-α（TNF-α） and multiple organ dysfunction syndrome（MODS） of patients after shock.Methods： 146 patients were randomly divided into early enteral nutrition group and total parenteral nutrition（TPN） group after shock.The serum endotoxin and TNF-α level were detected at 0、1d、3d and 5d respectively.The morbidity and mortality rates of MODS were compared between two groups of patients.Results： The serum endotoxin and TNF-α level of patients suffered from shock were significantly lower than those in TPN group after 5 days（P0.01）.The mortality of MODS was decreased from 58.33% to 23.53%（P0.05）.Conclusion： Early enteral nutrition can decrease the serum endotoxin and TNF-α level and the mortality rate of MODS in shock patients.
出处
《肠外与肠内营养》
CAS
北大核心
2011年第3期142-143,147,共3页
Parenteral & Enteral Nutrition
