摘要
乙型肝炎的发病机制主要是机体清除乙型肝炎病毒(hepatitis B virus,HBV)而引发的细胞免疫病理改变,机体对病毒的免疫应答有赖于一系列免疫活性细胞的相互作用.目前国内外主要就HBV感染控制者和感染持续者间的免疫差异原因进行研究.本文就乙型肝炎病毒感染状态下机体控制HBV感染下各相关免疫细胞间的作用机制以及对导致HBV特异免疫缺陷的因素(如高病毒抗原、CD4+T淋巴细胞、程序死亡-1、调节性T淋巴细胞和损伤的树突状细胞)作一综述.
The pathogenesis of hepatitis B is mainly triggered by the host＇s cellular immune responses to hepatitis B virus（HBV）infection,and the immune responses against the virus depends on the interaction of various immune cells.Current research of immunity to hepatitis B infection mainly focuses on understanding the differences between patients who can control HBV infection and those with persistent infection.In this paper,we analyze how immunological events influence the development of innate and adaptive immunity needed to control HBV infection and explore the mechanisms by which high levels of viral antigens,CD4 ＋ T cells,programmed death 1（PD-1）,the presence of regulatory T cells,and impaired dendritic cell functions maintain the HBV-specific immunological failure.
出处
《世界华人消化杂志》
CAS
北大核心
2011年第13期1381-1388,共8页
World Chinese Journal of Digestology
