摘要
目的:系统评价复方苦参注射液辅助化疗治疗肺癌的有效性。方法:计算机检索中国学术期刊全文数据库、中文科技期刊数据库、万方数据资源系统和中国生物医学文献数据库(CBMdisc)。按纳入与排除标准选择文献,对纳入研究的方法学质量进行评价,提取资料后采用RevMan4.2软件对数据进行Meta分析。结果:共纳入23篇文献,1750例患者。Meta分析结果显示,复方苦参注射液辅助化疗治疗肺癌的近期疗效优于单纯化疗[OR=1.68,95%C(I1.38,2.04),P<0.0001];对患者起到一定的疼痛缓解作用[OR=2.26,95%C(I1.61,4.27),P<0.0001];能明显提高患者的生存质量[OR=2.69,95%C(I1.97,3.68),P<0.00001]以及患者对化疗毒副反应的耐受性。结论:复方苦参注射液辅助化疗治疗肺癌能显著提高近期疗效,缓解患者疼痛,提高患者的生存质量以及患者对化疗毒副反应的耐受性。
OBJECTIVE： To evaluate the effectiveness of adjuvant therapy of compound Sophora flavescens injection in the treatment of lung cancer. METHODS： Relevant literatures were retrieved from CNKI, SWIC, Wanfang database and CBMdisc. Literatures were selected according to inclusion and exclusion criteria. Methodological qualities of included studies were evaluated and Meta-analysis was conducted using RevMan 4.2 software. RESULTS： 23 literatures were included, involving 1 750 patients. Results of Meta-analysis showed that the short-term curative effect of compound S. flavescens injection adjuvant chemotherapy was better than chemotherapy alone in the treatment of lung cancer [OR=1.68, 95%CI（1.38, 2.04）, P0.000 1]. Compound S. flavescens injection adjuvant chemotherapy relieved pain to certain extent [OR=2.26, 95%CI（1.61,4.27）, P0.000 1] and improved the life quality of patients [OR=2.69, 95%CI（1.97, 3.68）, P0.000 01] and the tolerability of patients to the toxicity of chemotherapy significantly. CONCLUSION： Compound S. flavescens injection adjuvant chemotherapy in the treatment of lung cancer improves the short-term curative effect, relieve pain of patients and improve the life quality of patients and the tolerability of patients to the toxicity of chemotherapy.
出处
《中国药房》
CAS
CSCD
北大核心
2011年第24期2267-2270,共4页
China Pharmacy
关键词
复方苦参注射液
肺癌
系统评价
Compound Sophora flavescens injection
Lung cancer
Systematic review
