摘要
目的:观察西沙必利联合双歧三联活菌治疗功能性消化不良(FD)的临床疗效。方法:将2009年6月-2010年6月在我院治疗的130例FD患者随机均分为2组,观察组65例采用西沙必利联合双歧三联活菌治疗,对照组65例仅采用西沙必利治疗,观察比较2组的临床疗效和主要症状变化。结果:观察组的总有效率(90.8%)明显高于对照组(67.7%),2组比较差异有统计学意义(P<0.05)。2组治疗后餐后饱胀、上腹胀痛、早饱和恶心评分均较治疗前下降,且差异有统计学意义(P<0.05)。观察组治疗后餐后饱胀、上腹胀痛、早饱和恶心评分均低于同期对照组,且差异有统计学意义(P<0.05)。结论:西沙必利联合双歧三联活菌治疗FD,较单用西沙必利能够明显提高临床疗效,改善患者临床症状。
OBJECITVE： To observe the clinical efficacy of cisapride combined with bifid triple viable in the treatment of functional dyspepsia （FD）. METHODS： From Jun. 2009 to Jun. 2010, 130 FD patients were randomly classified into 2 groups, which observation group with 65 cases was treated with cisapride combined with bifid triple viable and control group with 65 cases was only treated with cisapride. Clinical efficacy and main symptoms were observed and compared between 2 groups. RESULTS： The total effective rates（90.8%） in observation group were significantly higher than in control group（67.7%）, there was significant difference （P0.05）. Compared with pre-treatment, the scores of postprandial fullness, epigastric pain, early satiety and nausea were significantly decreased after treatment in both 2 groups, there were significant differences（P0.05）. Moreover, the scores of postprandial fullness, epigastric pain, early satiety and nausea in observation group after treatment were significantly lower than those in control group, there were significant differences （P0.05）. CONCLUSION： Cisapride combined with bifid triple viable in the treatment of FD can improve clinical efficacy and clinical symptoms significantly, compared with cisapride alone.
出处
《中国药房》
CAS
CSCD
北大核心
2011年第24期2251-2252,共2页
China Pharmacy
