摘要
目的 比较自由落体和液压致大鼠脑损伤模型的异同。方法 建立两种类型的创伤模型，观察伤后不同时间的行为学、组织学和脑水含量变化。结果 在４８ 小时死亡率相近的情况下（ 自由落体３１ ．８ ％ 、液压３２ ．５ ％ ） ，自由落体损伤后症状表现较轻，恢复较慢，受伤局部损伤严重，周围皮质水肿明显；液压损伤后症状表现较重，但恢复迅速，损伤范围广，而受伤局部损伤较轻，周围皮质没有水肿。结论行为学、组织学改变的不同，表明两种模型有着不同的致伤机理和应用范围。
Objective To compare the contusion (CT) and fluid percussion (FP) brain injury model in rats. Methods Neurological symptoms, brain histological alterations and water contents were studied after injury. Results The 48 h mortality was similar (31.8% for CT and 32.5% for FP). CT group showed milder symptoms, slower recovery, severe local tissue damage and peripheral edema. FP group showed severe but temporary symptoms, widespread cerebral tissue involvement, but no remarkable edema. Conclusion The traumatic mechanisms and the application for these two models are differ ent.
出处
《中华实验外科杂志》
CAS
CSCD
北大核心
1999年第5期447-448,共2页
Chinese Journal of Experimental Surgery
基金
卫生部资助项目
