摘要
目的 对目前临床常用的免疫指标进行优选,以期能更快、更准确、更经济地诊断与监测类风湿性关节炎.方法 同步检测类风湿关节炎患者血液的类风湿因子（RF）、C反应蛋白（CRP）、红细胞沉降率（ESR）、抗环瓜氨酸肽抗体（anti-CCP）、抗角蛋白抗体（AKA）、葡萄糖-6-磷酸异构酶抗原（CPI）、抗突变型瓜氨酸化波形蛋白抗体（anti-MCV）,比较其敏感性与特异性.结果 anti-MCV敏感性76.8%,特异性90.6% anti-CCP 67.2%,90.3% AKA 75.2%,84.7% RF 72.8%,79.1% GPI特异性（92.1%）较好,但敏感性（46.4%）较差 其他项目特异性和敏感性均不好.结论 anti-MCV、anti-CCP、AKA、RF可作为临床对类风湿性关节炎的诊断、治疗和疗效监控的优选指标.
Objective To optimize the immunologic diagnostic criteria of rheumatoid arthritis commonly used in clinical,to find methods to diagnose rheumatoid arthritis quickly,accurately and economically.Methods The levels of RF,CRP,ESR,anti-CCP,AKA,CP I,anti-MCV in blood of the patients with rheumatoid arthritis were simultaneously measured, and their sensitivity and specificity was compared.Results The sensitivity and specificity of antiMCV was 76.8% and 90.6% ,anti-CCP 67.2% and 90.3% ,AKA 75.2% and 84.7% ,RF 72.8% and 79.1%.The sensitivity and specificity of them were higher.The specificity of GPI（92.1% ） was high,but the sensitivity of it （46.4% ）was low.The sensitivity and specificity of other criteria were low.Conclusion anti-MCV,anti-CCP,AKA and RF could be preferentially used in the diagnosis,therapy and monitor of curative effect of rheumatoid arthritis.
出处
《中国基层医药》
CAS
2011年第12期1643-1644,共2页
Chinese Journal of Primary Medicine and Pharmacy
关键词
类风湿性关节炎
诊断指标
优选
Rheumatoid arthritis Diagnostic criteria Optimizing
