摘要
目的探讨潜在危险因素对宫颈癌及癌前病变的影响。方法收集本市三家市级医院确诊并尚未治疗过的宫颈癌92例、宫颈上皮内瘤样变Ⅲ级（即CINBI）63例及正常组252例，分析各因素与宫颈癌发病的关系。结果单因素分析显示妇科疾病史（X^2=19．3l，P〈0.01）、月经初潮年龄（F=11．62，｜p〈0．01）、首次性生活年龄（F=25．76，P〈0．01）、首次生育年龄（F=28．02，P〈0．01）、怀孕次数（F=13．98，P〈0．01）、分娩次数（F=4．78，P〈0．01）、文化程度（X^2=10．70，P〈0．05）、HPV感染（X^2=179．95，P〈0．01）、叶酸水平（F=3．39，P〈0．05）（与宫颈癌及癌前病变的发生均有相关性（P〈0．05），而叶酸与维生素B．，呈正相关相关系数r=0．482，P〈0．05）；Logistic回归显示经常饮茶（OR=0．321，β=-1．136，P〈0．05）、性生活后洗外生殖器的习惯（OR=0．387，β=-0．950，P〈0．05）、首次性生活年龄越迟（OR=0．55J，／3=0．596，P〈0．05）、体内叶酸水平越高（OR=0．502，／3=一0．688，P〈0．01）是宫颈癌发病的保护因素；HPV感染（OR=27．215，口=3．304，P〈0．01）、分娩次数越多（OR=1．846，／3=0．613，P〈0．05）及有被动吸烟史（OR=1．673，口：0．515，P〈0．05）则是宫颈癌发病的危险因素。结论体内叶酸水平越高，宫颈癌的发病可能性越低，首次性生活年龄偏早、性生活后未洗外生殖器、HPV感染、多次孕产史及长期处于被动吸烟状态对宫颈癌的发病有影响，有饮茶习惯、补充叶酸及维生素B，：可能有预防宫颈癌发病的作用。
Objective To discuss about the relationship between the occurrence of the uterine cer- vix cancer and the risk factors. Methods Among the patients we collected, 92 patients were diagnosed to have the cervical cancer, 63 patients were diagnosed as CIN III（ the cervical intraepithelial neoplasia, CIN） , and 252 patients belonged to the control group. All patients had not been cured before. We used the questionnaire to investigate them about the dietary habit and other information. Through using different statistical methods, we explored the relationship between the cervical cancer and the potential factors. Results We found out that many factors contributed to the happening of the cervical cancer, such as gynecopathy （X2 = 19.31, P 〈0. 01）, the first time of the menses（ F = 11.62, P 〈0. 01）, the first time of the sex life（ F =25.76, P 〈0. 01 ） , the first time of the parturition （ F =28.02, P 〈0. 01 ） , the times of the pregnancy and the parturition（ F1 = 13.98, P~ 〈0. 01 ; F2 =4. 78, P2 〈0. 01 ） ,the culture degree（x^2 = 10. 70, P 〈0. 05）, the infection of HPV（X^2 = 179. 95, P 〈0. 01） ,the level of the folic acid （ F =3.39, P 〈 0. 05 ） and so on. The result of the logistic regression analysis showed that keeping the habit of drinking tea （ OR = 0. 321,/3 = - 1. 136, P 〈 0. 05 ） ,paying attention to the sanitation of the sex life（ OR = 0. 387, β= O. 950, P 〈 O. 05 ） ,putting off the first time of the sex life（ OR = O. 551,β = - O. 596, P 〈 O. 05 ）, and the higher level of the folic acid （ OR = O. 502,β= - O. 688, P 〈 O. 05） were the protective factors tothe occurrence of the uterine cervix cancer. Meanwhile, the infection of the HVV （ OR = 27. 215, β = 3. 304, P 〈0. O1 ）, many times of the parturition（ OR = 1. 846, β =0. 613, P 〈0. 05） and the passive smoking （ OR = 1. 673, β = 0. 515, P 〈 0.05 ） were the risk factors. Conclusions With the higher level of the folie acid,the less possibility you will get the cervic
出处
《中国医师杂志》
CAS
2011年第4期447-450,共4页
Journal of Chinese Physician
基金
基金项目：福建省厦门市重大疾病攻关课题（XMWZK0602）
关键词
宫颈肿瘤/病理学
危险因素
Uterine cervical neoplasms/PA
Risk factors
