摘要
目的 探讨不良妊娠与弓形体（ Ｔ Ｏ Ｘ） 、其他（ Ｏ Ｔ Ｈ） 、风疹病毒（ Ｒ Ｕ Ｖ） 、巨细胞病毒（ Ｃ Ｍ Ｖ） 、单纯疱疹病毒（ Ｈ Ｓ ＶⅡ）（ Ｔ Ｏ Ｒ Ｃ Ｈ） 系列病原体感染的关系。方法 应用酶联免疫吸附试验（ Ｅ Ｌ Ｉ Ｓ Ａ） 和聚合酶链反应（ Ｐ Ｃ Ｒ） 技术，检测５４ 例有不良妊娠史的妇女（ 试验组） 及５４ 例正常孕妇（ 对照组） 母血及胎儿脐血 Ｔ Ｏ Ｒ Ｃ Ｈ 感染情况。结果 （１） 试验组 Ｔ Ｏ Ｒ Ｃ Ｈ 既往感染率为， Ｃ Ｍ Ｖ４６ ．２９ ％ ； Ｒ Ｕ Ｖ１６ ．２９ ％ ； Ｔ Ｏ Ｘ１６ ．６７ ％ ； Ｈ Ｓ ＶⅡ２９ ．６３ ％ 。（２） 试验组 Ｔ Ｏ Ｒ Ｃ Ｈ 活动性感染率为， Ｃ Ｍ Ｖ５７ ．４０ ％ ； Ｒ Ｕ Ｖ５９ ．２６ ％ ； Ｔ Ｏ Ｘ ３８ ．８９ ％ ； Ｈ Ｓ ＶⅡ４６ ．２９ ％ 。（３） 试验组 Ｔ Ｏ Ｒ Ｃ Ｈ 复发感染率为， Ｃ Ｍ Ｖ ３８ ．８９ ％ ； Ｒ Ｕ Ｖ３８ ．８９ ％ ； Ｔ Ｏ Ｘ１１ ．１１ ％ ； Ｈ Ｓ ＶⅡ２２ ．２２ ％ 。以上３ 个指标，试验组均显著高于对照组（ Ｐ＜ ０ ．０１） ，异常妊娠结局发生率试验组亦显著高于对照组（ Ｐ＜ ０ ．０１） 。试验组 Ｔ Ｏ Ｒ Ｃ Ｈ 母婴垂直传播率为７３ ．０８ ％ 。
Objective To investigate the relationship between the history of abnormal pregnancy and the Toxoplasma(TOX),Other(OTH),Rubella virus(RUV),Cytomegalo virus(CMV),Herpes simplex virus Ⅱ(HSV Ⅱ) (TORCH) infections in pregnant woman. Methods Enzyme Linked immunosorbent assay(ELISA)combind with polymerase chain reaction (PCR) technique were used to detect TORCH infection in pregnant women with histories of abnormal pregnancies(study group, n=54)and normal pregnant women (control group, n=54).The fetal cord blood samples were also detected. Results In study group,the rates of previous TORCH infection: CMV 46.29%, RUV 16.29%, TOX 16.67%, HSV Ⅱ 29.63%. The rates of active infection: CMV 57.40%, RUV 59.26%, TOX 38.89%, HSV Ⅱ 46.29%. The rates of recurrent infection:CMV 38.89%, RUV 38.89%, TOX 11.11%, HSV Ⅱ 22.22%. These three kinds of infection rates in study group were significantly higher than that of control group ( P <0.01). The abnormal pregnant cntcomes in study group were significantly higher than that of control group( P <0.01). The incidence of maternal fetal vertical transmission in study group was 73.08%. Conclusion TORCH series infection is one of the important causes of abnormal pregnant cutcomes. It is absolutely necessary to screen TORCH infection for women who had the histories of abnormal pregnancies in order to prevent birth defects and perinatal complications. ELISA combined with PCR technique is a valuable method for the diagnosis of TORCH infection.
出处
《中华妇产科杂志》
CAS
CSCD
北大核心
1999年第9期517-520,共4页
Chinese Journal of Obstetrics and Gynecology
基金
安徽省教委科研基金
关键词
弓形虫病
风疹
不良妊娠
TORCH感染
Toxoplasmosis Rublla Cytomegalovirus infectons Pregnancy outcome Polymerase chain reaction
