摘要
目的:探讨丹银提取物对血管性痴呆(VD)模型大鼠学习记忆的影响。方法:60只SD大鼠随机分为VD模型组、假手术组及丹银治疗组,采用改良的4-VO法建立VD模型大鼠,丹银治疗组术后给予丹银提取物灌胃治疗;用Morris水迷宫检测各组大鼠的学习记忆功能,海马HE染色观察神经元变化。结果:与VD组比较,经丹银提取物治疗后,VD大鼠学习记忆能力明显改善,海马神经元损伤减少。结论:丹银提取物能改善VD大鼠学习记忆能力,其机制可能是减少海马神经元损伤。
Objective： To observe the effects of extracts from Ginkgo biloba leaves and salvianolic acid B（DanYin extracts）on learning and memory abilities of rats with vascular dementia（VD）.Methodes： The VD model rats were established with modified 4-VO method and was treated with DanYin extracts.Morris water maze was used to detect learning and memory capacities of the rats.Results： After treated with DanYin extracts,learning and memory capacities of VD rats significantly improved,and the number of injured neurons in hippocampus was decreased.Conclusion： DanYin extracts can improve learning and memory capacities of VD model rats.
出处
《贵阳医学院学报》
CAS
2011年第2期168-170,共3页
Journal of Guiyang Medical College
关键词
痴呆
血管性
丹参
银杏
学习记忆能力
大鼠
dementia
vascular
salvia miltiorrhiza
Ginkgo biloba
learning and memory ability
rats
