摘要
目的比较冠心病患者行非心脏手术时七氟醚与丙泊酚对心肌的影响。方法40例心功能工或Ⅱ级择期行上腹部手术的冠心病患者随机分为丙泊酚组（PR组）与七氟醚组（SE组）。PR组丙泊酚靶控输注血药浓度维持在2～3μg／ml，SE组呼气末七氟醚浓度维持在2%～3％，连续监测血流动力学及ECG变化，检测麻醉前与术毕血清白细胞介素一6（II，6）、肿瘤坏死因子α（TNF-α）、心肌钙蛋白（cTnI）及糖原磷酸化酶BB（GP-BB）浓度。结果术毕PR组血清IL-6、TNF-a、cTnI及GP-BB浓度明显高于麻醉前及SE组（P〈0．05）。结论冠心病行非心脏手术时七氟醚对心肌的保护效应优于丙泊酚。
Objective To compare the effect of sevoflurane and propofol on cardiac protection undergoing noncardiac surgery in patients with coronary artery disease. Methods Forty patients with coronary artery disease and heart function scale of I or II scheduled for epigastric operation were randomly divided into two groups with 20 cases each. Group PR received target-controlled infusion of propofol and maintained the blood concentration at 2-3 μg/ml, and group SE received sevoflurane with the end expiration concentration of sevoflurane at 2 0%-3% Hemodyaamics and ECG were monitored continuously, and the levels of IL-6, TNF-α, cTnI and GP-BB was measured before and after surgical procedures. Results The levels of IL-6, TNF-α, cTnI and GP-BB were elevated after operation than prior to operation （P〈0. 05）, and they were higher in the group PR than those in the group SE （P〈 0. 05）. Conclusion Sevoflurane had superior protective effect on myocardium to propofol in patients undergoing noneardiac surgery who with coronary artery disease.
出处
《临床麻醉学杂志》
CAS
CSCD
北大核心
2011年第5期442-444,共3页
Journal of Clinical Anesthesiology
关键词
七氟醚
丙泊酚
冠心病
心肌
sevoflurane
propofol
coronary artery disease
mycardium
