摘要
利用锂钙硼玻璃在磷酸盐溶液中的原位转化反应制备表面多孔的中空羟基磷灰石(HAP)微球。通过扫描电镜(SEM)、电子能谱(SEM-EDS)、X射线衍射(XRD)仪、和红外光谱(FTIR)仪分析微球的形貌和物相,研究与探讨中空HAP微球的形成与转化机制。结果表明:所制备的微球具有良好的中空结构;中空微球物相为包含B型碳酸根的缺钙羟基磷灰石,具有仿生性。600℃热处理后,微球球壳完全由包含碳酸根的缺钙羟基磷灰石晶体组成,并显示出一定的机械强度。在磷酸盐溶液中,锂钙硼玻璃表面原位生成Ca-P-OH水化物,并在玻璃表面原来Ca2+的位置沉积下来,形成微球壳,而由Li+和B3+占据的位置,因其溶出形成孔隙。这样的结构将有利于制备表面多孔的中空羟基磷灰石多孔贮库型药物释放系统的载体。
Hollow hydroxyapatite（HAP） microspheres with pores on their surfaces were prepared by in situ conversion reaction of Li-Ca-B glass in phosphate solution.The morphology and phase composition of the microspheres were investigated using SEM,SEM-EDS,XRD and FTIR.The formation and conversion mechanism of the hollow HAP microspheres during the immersion process was studied.The results show that the prepared microspheres possess good hollow structures.The phase of the microspheres is calcium-deficient hydroxyapatite containing B-type CO32-,which is biomimetic.After 600 oC heat treatment,hollow microspheres＇ shells are completely composed of calcium-deficient hydroxyapatite containing CO32-and exhibit the necessary mechanical strength.In the phosphate solution,Ca-P-OH hydrate is in-situ formed on the surface of the Li-Ca-B glass and precipitates at the positions occupied by Ca2＋ to form microsphere shell,while the pores are formed at the positions occupied by Li＋ and B3＋.Such structures are good for the preparation of hollow HAP as the carriers of the porous reservoir drug release system.
出处
《稀有金属材料与工程》
SCIE
EI
CAS
CSCD
北大核心
2011年第5期930-934,共5页
Rare Metal Materials and Engineering
基金
上海市科委"创新行动计划"基础研究重点项目(08JC1419200)
关键词
缺钙羟基磷灰石
中空微球
B型碳酸根
硼酸盐玻璃
原位合成
calcium-deficient hydroxyapatite
hollow microspheres
B-type CO32-
borate glass
in situ synthesis
