摘要
目的探讨归脾丸对慢性特发性血小板减少性紫癜患者血小板相关抗体水平的影响。方法慢性特发性血小板减少性紫癜患者60例,随机分为归脾丸治疗组及西药治疗对照组各30例,应用酶联免疫竞争抑制试验(ELISA)定量测定每组治疗前、治疗后1个月及治疗后3个月的血小板相关抗体水平。结果两组治疗前的PAIgG、PAIgA、PAIgM均无明显差异(P>0.05),经3个月的治疗后再检测两组的PAIgG、PAIgA、PAIgM与各组治疗前相比均有明显下降,有显著意义(P<0.05),两组治疗后的PAIgG、PAIgA、PAIgM相比无明显差异(P>0.05)。结论归脾丸可能通过其组方中的多种药物的免疫抑制或调节作用来抑制慢性特发性血小板减少性紫癜患者血小板相关抗体的产生而达到治疗目的。
Objective：To probe into the effects of Gui Pi pills on the level of platelet-associated antibodies of patients with chronic idiopathic thrombocytopenic purpura.Methods： 60 cases of patients with chronic idiopathic thrombocytopenic purpura were randomized into three groups： the Gui Pi pills group,the western medicine group,and the control group.There were 30 cases in each group.The levels of platelet-associated antibodies of each group 1 month before and after treatment,and 3 months after the treatment were determined with ELISA.Results： The levels of PAIgG,PAIgA and PAIgM of the two therapeutic groups had no obvious difference before the treatment（P0.05）.After 3 months＇ treatment,the levels of PAIgG,PAIgA and PAIgM of each group had obvious decrease,and the difference was significant（P0.05）.The levels of PAIgG,PAIgA and PAIgM between the two therapeutic group didn＇t have obvious difference（P0.05）.Conclusion： Some ingredients in Gui Pi pill may inhibit the production of platelet-associated antibodies of patients with chronic idiopathic thrombocytopenic purpura by immune suppression or regulating for therapeutic purposes.
出处
《现代中医药》
CAS
2011年第3期1-3,共3页
Modern Chinese Medicine
关键词
血小板减少性紫癜
慢性特发性
归脾丸
血小板相关抗体
thrombocytopenic purpura
chronic idiopathic
Gui Pi pills
platelet-associated antibody
