摘要
综述脱落酸(abscisic acid,ABA)在人和动物细胞中的存在和分泌、对各种组织细胞的作用及其信号途径等方面的研究进展.从海绵动物到多种哺乳动物的各种白细胞、胰岛细胞和干细胞等都能产生或分泌ABA,通过激活质膜上的G蛋白偶联复合受体,激活细胞内的腺苷二磷酸核糖环化酶,使细胞环腺苷二磷酸核糖升高,从而导致细胞内Ca2+浓度升高,诱导细胞内各种生理生化反应.ABA能刺激各种白细胞和巨噬细胞的免疫反应,刺激胰岛细胞释放胰岛素,刺激间质干细胞和造血祖细胞的增大和功能,抑制癌细胞的生长和诱导其分化等.ABA是生物界广泛存在和通用信号因子,可能用于多种人类疾病的治疗.
Abscisic acid（ABA） is an important phytohormone regulating plant growth,development,dormancy and plant responses to abiotic stresses.Recently,ABA is demonstrated to be produced by wide range of animals from sponges to various human tissues and cells,such as leukocytes,pancreatic cells,mesenchymal stem cells and to stimulate functions through a signaling pathway involving the intracellular cyclic ADP-ribose and Ca2＋.Endogenous ABA stimulates immune responses in leukocytes and macrophages,the release of insulin in islet cells,the expansion of mesenchymal and colon stem cells,inhibits growth and induces differentiation of cancer cells.Research indicates that ABA is a universal signal and has potential applications in several human diseases.This article summarizes recent advances on the existence,signal pathways and functions of ABA in animal and human cells.
出处
《华南师范大学学报（自然科学版）》
CAS
北大核心
2011年第2期7-12,共6页
Journal of South China Normal University(Natural Science Edition)
基金
广东省自然科学基金项目(10151063101000002)
广州市科技支撑项目(2008Z1-E591)
广州市番禺区科技项目(2009-T-17-1)
关键词
脱落酸
哺乳动物
药理作用
信号途径
免疫调节
Abscisic acid
human
pharmacological function
signal pathway
immune regulation
