摘要
目的研究甲状腺结节的MR PWI表现与血管生成表现相关关系,评价PWI鉴别结节良恶性的价值。方法对62例甲状腺结节患者行PWI扫描。所有病例均得到时间-信号曲线(TIC)、最大斜率(SS)、峰值强化(PE)和达峰时间(TTP)。其中50例测量微血管密度(MVD)及血管内皮生长因子(VEGF),并与灌注参数进行相关性分析。结果甲状腺结节的TIC可分为4种类型,恶性结节均表现为Ⅰ型曲线,84.62%(44/52)的良性结节表现为Ⅱ型和Ⅲ型曲线;良恶性结节间各灌注参数值差异无统计学意义,三种良性病变间的SS值差异有统计学意义(P<0.05);良恶性结节间VEGF差异有统计学意义(P<0.01),而MVD差异无统计学意义;甲状腺结节的灌注参数SS与MVD、PE与MVD和VEGF呈线性正相关(r=0.49、0.49、0.55,P<0.05),TTP值与MVD和VEGF均无相关性。结论 MR PWI对甲状腺良恶性结节的鉴别诊断有一定的意义;SS和PE值能一定程度上反映结节的血管生成情况。
Objective To investigate the relationship between MR perfusion weighted imaging（PWI） findings and tumor angiogenesis of thyroid nodules,and to assess the values of PWI in differentiating malignant from benign nodules.Methods MR PWI was performed in 62 patients with thyroid nodules.Time-signal intensity curve（TIC）,steepest slop（SS）,peak enhancement（PE） and time to peak（TTP） were obtained.Microvessel density（MVD） and vascular endothelial growth factor（VEGF） were measured and compared with perfusion parameters in 50 cases.Results All malignant nodules presented TypeⅠ curve,and type Ⅱ and Ⅲ curve were seen in 84.62%（44/52） of benign nodules.There were significant differences among three benign groups,but no significant difference between malignant and benign nodules of SS,PE and TTP was found.There were significant differences between malignant and benign nodules in VEGF（P〈0.01）,but not in MVD.There were good linear correlation between SS and MVD,PE and MVD,PE and VEGF（r=0.49,0.49,0.55,P〈0.05）.Conclusion MR PWI is a reliable method for discriminating malignant from benign thyroid nodules.SS and PE can reflect angiogenesis of nodules in certain extent.
出处
《中国医学影像技术》
CSCD
北大核心
2011年第5期930-934,共5页
Chinese Journal of Medical Imaging Technology
