摘要
目的:探讨尼可胺对荷H22肝癌小鼠的放射增敏作用。方法:建立H22肝癌小鼠模型,按照给药和照射的不同,分为空白对照组、单纯照射组、阳性对照(烟酰胺、甘氨双唑钠)组、尼可胺(高、中、低)组。经照射后,观察H22肝癌小鼠肿瘤生长情况,记录肿瘤照射后生长时间,计算肿瘤生长延缓时间及各组的增敏系数(EF)。照射后28d时处死小鼠,剥瘤称质量,计算抑瘤率。结果:尼可胺高、中、低组较单纯照射组均能增加辐射敏感性,抑制肿瘤的生长,且尼可胺高剂量组的增敏系数和抑瘤率均高于其母体化合物烟酰胺和甘氨双唑钠,差异均有统计学意义(均P<0.05或P<0.01)。结论:较高剂量的尼可胺对H22肝癌小鼠肿瘤生长有较强的抑制作用和放射增敏效果。
Objective：To investigate the radiosensitizing effects of NiKeAn on H22 hepatoma-bearing mice.Methods：The mouse hepatoma H22 model was established.The model mice were divided into blank control group,pure radiation group,positive control group and NiKeAn（high,medium and low doses）group.After mice were irradiated,the tumor growth was observed,the epigenetic tumor irradiation time was recorded,and the delay time of tumor growth and enhancement factor（EF）were calculated.After 28 days,mice were killed.Tumors were stripped and the inhibition rate was calculated.Results：The radiosensitizing effect and tumor-inhibition rate were more higher in NiKeAn（high,medium and low doses）group than those of pure radiation group.The enhancement factor and inhibition rate were higher in NiKeAn group（high dose） than those of sodium glycididazole group and nicotinamide group（P 0.05 or P 0.01）.Conclusion：NiKeAn in a higher dose can inhibit the tumor growth,and has radiosensitizing effects on H22 hepatoma-bearing mice.
出处
《天津医药》
CAS
北大核心
2011年第5期442-444,共3页
Tianjin Medical Journal
基金
天津市科技计划项目(项目编号:09ZCKFSH)
关键词
肝肿瘤
癌
辐射增敏药
剂量效应关系
药物
疾病模型
动物
小鼠
尼可胺
liver neoplasms carcinoma radiation-sensitizing agents dose-response relationship
drug disease models
animal mice NiKeAn
