摘要
目的:观察甘氨双唑钠对中晚期鼻咽癌放射治疗的临床疗效和不良反应。方法:44例中晚期鼻咽癌患者随机分为两组,治疗组(放射治疗+CMNa)22例,对照组(单纯放疗)22例,治疗组同时使用CMNa 800mg/m2,每周3次,从放疗开始连续使用至放疗结束,两组放疗方法相同,均为常规放疗,原发灶和颈部淋巴结剂量7200-7400cGy/36-37f/7-8w。结果:治疗组和对照组患者治疗结束时肿瘤原发灶的完全消退率(CR率)分别为90.7%,72.7%,放疗剂量分别为5102cGy,6133cGy,χ2=2.444,P<0.05;颈部淋巴结CR率分别为86.4%,68.2%,放疗剂量分别为4702cGy,5646cGy,χ2=1.600,P<0.05,差异有统计学意义。结论:CMNa合并放疗治疗中晚期鼻咽癌有增敏作用,可提高肿瘤局部控制率,而不良反应无明显增加。
Objective：To observe the clinical effect and toxicity of CMNa on the radiotherapy of advanced nasopharyngeal carcinoma.Methods：Total of 44 patients with advanced nasopharyngeal carcinoma were divided into two groups randomly：treatment group（n=22） and control group（n=22）.The patients in treatment group were intravenous dripped CMNa 800mg/m2 three times weekly during whole treatment period,patients in control group were treated with radiotherapy alone.All patients underwent the same radiotherapy.The doses for nasopharyngeal and neck lymph node were 7200-7400cGy/36-37f/7-8w.Results：The complete regression（CR） rates of nasopharyngeal in treatment group and control group were 90.7% and 72.7% respectively,the CR rates of neck lymph node were 86.4% and 68.2% respectively,there were significant difference between two groups,P0.05.That doses of nasopharyngeal by which the effects had reached CR were 5102cGY and 6133cGY respectively,while neck lymph node were 4702cGY and 5646cGY respectively,there was significant difference between two groups,P0.05.Conclusion：CMNa could enhance radiosensitivity and raise the local control rate of advanced nasopharyngeal carcinoma while without obvious toxicity.
出处
《现代肿瘤医学》
CAS
2010年第11期2137-2138,共2页
Journal of Modern Oncology
