摘要
目的：探讨骨肿瘤复发前后在细胞的多药耐药性和凋亡方面的变化。方法：应用免疫组化和流式免疫学方法测定Ｐ１７０、ｂｃｌ－２蛋白在８例骨肿瘤复发前后的１６个标本中的表达，男６例，女２例。年龄平均３０６岁。良性肿瘤２例，恶性肿瘤６例。结果：２例良性肿瘤在复发前后Ｐ１７０、ｂｃｌ－２蛋白表达无明显差异。６例恶性肿瘤中，原发仅２例Ｐ１７０为阳性，复发后５例为阳性；复发后ｂｃｌ－２含量明显高于原发（Ｐ＜００５）。结论：恶性骨肿瘤复发后细胞的多药耐药性和增殖能力有增强的趋势。
Objective:To investigate the changes of multidruy resistance and cell programic death recurrent bone tumor.Method:Using immunohistochmistry and flow cytometric method.The expressions of p170、bcl-2 protein in 16 samples from 8 cases of recurrent bone tumor were measured.There were 6 in males,2 in females,and with the mean age of 30 6 years old,there were 2 in benign,6 in malignant bone tumor.Result:There were no different expressions of P170、bcl-2 protein between the primary and the recurrent in 2 benign tumor.In 6 malignant tumors,only 2 were positive expressions of p170 in primary,5 in recurrent.The bcl-2 content in recurrent tumor were much higher than that in primary( P <0 05).Conclusion:the multidrug resistance of the recurrent malignant tumor were enhanced and the cell programic death of malignant tumor cell were inhabited.
出处
《中国矫形外科杂志》
CAS
CSCD
1999年第8期575-576,共2页
Orthopedic Journal of China
