摘要
目的:考察甲磺酸酚妥拉明注射液与二羟丙茶碱注射液在0.9%氯化钠注射液和5%葡萄糖注射液中的配伍稳定性。方法:将甲磺酸酚妥拉明注射液与二羟丙茶碱注射液分别加入到250mL0.9%氯化钠注射液和5%葡萄糖注射液中混合,在25℃恒温下放置。采用高效液相色谱法测定配伍前、后不同时间的酚妥拉明和二羟丙茶碱含量,同时观察配伍液的外观并测定pH值。结果:2种配伍液均澄明无色,pH值、含量在放置24h内基本无变化。结论:甲磺酸酚妥拉明注射液与二羟丙茶碱注射液在0.9%氯化钠注射液和5%葡萄糖注射液中配伍后于25℃放置24h稳定。
OBJECTIVE： To investigate the compatible stability of Phentolamine mesilate injection and Diprophylline injection in 0.9% Sodium chloride injection and 5% Glucose injection. METHODS： Phentolamine mesilate injection and Diprophylline injection were added into 250 mL 0.9% Sodium chloride injection or 5% Glucose injection respectively. Mixture was stored at 25 ℃. The contents of phentolamine mesilate and diprophylline were determined by HPLC before and after mixture at different time points. Appearance and pH values of mixture were observed. RESULTS： 2 kinds of mixtures were clear and colorless. The pH value and contents of mixture exhibited little change within 24 h. CONCLUSION： Phentolamine mesilate injection and Diprophylline injection in 0.9% Sodium chloride injection and 5% Glucose injection are stable for 24 h at 25 ℃.
出处
《中国药房》
CAS
CSCD
北大核心
2011年第22期2062-2064,共3页
China Pharmacy
