摘要
毛囊隆突区存在着干细胞群，有角质形成干细胞、多能神经嵴干细胞和可以形成黑素细胞体系的于细胞等。它们具有成体干细胞的分裂增殖能力和分化潜能，其中毛囊隆突区的神经嵴干细胞在一定的条件下可以分化为神经元、神经胶质细胞和黑素细胞等，而且将这类干细胞移植人受伤的神经，它们可以促进神经细胞的再生和修复。就毛囊隆突区具有神经分化潜能的干细胞的定位、分化为神经的特性等进行综述，从而进一步探讨其在再生医学上的应用。
The bulge of hair follicles contains a mixed population of stem cells,including epidermal stem cells, neural crest stem cells, as well as another type of stem cells which can be induced into melanocytes. Bulge stem cells have the ability to divide, proliferate and are pluripotent as other adult stem cells. The neural crest stem cells can differentiate in vitro into neurons, glia and melanocytes under proper induction. Meanwhile, it was proved that implanting these cells into the gap region of damaged nerves could greatly enhance the regeneration rate of nerve and restoration of nerve function. In this review, distribution of the stated stem cells in hair follicle bulge and their characteristics of differentiating into neurons were discussed, as well as their possible application in regenerative medicine.
出处
《国际生物医学工程杂志》
CAS
北大核心
2011年第2期126-128,共3页
International Journal of Biomedical Engineering
关键词
皮肤干细胞
神经分化
再生医学
Epidermal stem cells
Differentiate into neurons
Regenerative medicine
