摘要
目的:观察桑椹多糖对链脲佐菌素(STZ)和高能量饲料诱发的2型糖尿病(T2DM)模型大鼠血糖、血脂的影响。方法:高糖高脂饲料喂养4周后,ip 30 mg·kg-1STZ建立T2DM大鼠模型,随机分为糖尿病模型对照组、桑椹多糖低剂量组(ig150 mg·kg-1·d-1)、中剂量组(ig 300 mg·kg-1·d-1)、高剂量组(ig 450 mg·kg-1·d-1)及罗格列酮治疗组(ig 4 mg·kg-1·d-1)。持续ig给药60 d后测空腹血糖(FBG)、血脂、糖化血红蛋白(HbAlc)、胰岛素(Ins)的含量。结果:桑椹多糖治疗组与模型组比较,FBG,HbAlc,甘油三酯(TG)、总胆固醇(TCH)及低密度脂蛋白(LDL)水平显著降低(P<0.05),高密度脂蛋白(HDL)和Ins水平显著升高(P<0.05)。结论:桑椹多糖能有效地降低T2DM模型大鼠的血糖,促进Ins分泌,调节血脂。
Objective：To observe the influence of Mori Fructus polysaccharide（FMP） on blood glucose,serum lipoprotein in diabetic rats induced by streptozotocin（STZ） and high-energy diet.Method： Type 2 diabetes model was induced with high sucrose-fat diet for 4 weeks and STZ ip at 30 mg·kg-1.Rats were randomly divided into groups： model group,FMP low dose（ig 150 mg·kg-1·d-1）and middle dose（ig 300 mg·kg-1·d-1）and high dose treatment group（ig 450 mg·kg-1·d-1）,rosiglitazone treatment group（ig 4 mg·kg-1·d-1）.Blood glucose,serum lipoprotein,HbAlc,Ins contents in rats were detected after 60 d of continuous medication.Result： Compared with the model group,FMP could significantly reduce the levels of blood glucose,HbAlc,TG,TCH and LDL（P0.05）,and improve the level of HDL and Ins（P0.05）.Conclusion： FMP can effectively reduce rat＇s blood glucose of T2DM,promote Ins secretion,regulate serum lipoprotein.
出处
《中国实验方剂学杂志》
CAS
北大核心
2011年第10期158-160,共3页
Chinese Journal of Experimental Traditional Medical Formulae
基金
国家科技部国际科技合作项目(2008DFA31050)
关键词
桑椹多糖
2型糖尿病
血糖
血脂
Mori Fructus polysaccharide
type 2 diabetes mellitus
blood glucose
serum lipoprotein
