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2型糖尿病患者胰岛素样生长因子-2与骨密度的关系 被引量:4

Relationship between Insulin-Like Growth Factor 2(IGF-2) and Bone Mineral Density in Patients with Type2 Diabetes
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摘要 目的:研究2型糖尿病患者病程、空腹C肽水平、骨密度与血清胰岛素样生长因子-2(IGF-2)的关系。方法:96例2型糖尿病患者,均测量身高、体质量、骨密度、骨密度以及空腹血清C肽和IGF-2水平。分析糖尿病病程、IGF-2、骨量以及空腹C肽水平之间的关系。结果:随着糖尿病病程延长,IGF-2水平下降;随着骨密度水平下降,IGF-2水平下降;随着空腹C肽水平下降,IGF-2水平下降。结论:IGF-2可能参与了2型糖尿病的进程和骨质疏松的发生。 Objective:To study the relationship between the serum level os insulin-like growth factor 2(IGF-2) and bone mineral density(BMD) in patients with type2 diabetes(DM).Methods:Height,weight,fasting serum C-peptide,IGF-2,and BMD were measure in 96 patients with DM.The associations among the levels of IGF-2,C-peptide and BMD were analyzed.Results:As the years of being DM gets longer,the level of IGF-2 gets lower.BMD was positively related with the lever of IGF-2.When the level of C-peptide decreased,the level of IGF-2 tended to be lower.Conclusions:IGF-2 may contribute to the DM outbreak and the occurrence of osteoporosis.
出处 《中国临床医学》 2011年第2期196-197,共2页 Chinese Journal of Clinical Medicine
关键词 2型糖尿病 胰岛素样生长因子-2 C肽 骨质疏松 Type 2 diabetes Insulin-like growth factor 2 C-peptide Osteoporosis
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  • 1Higashi Y,Takenaka A,Takahashi S,et al.Effect of proteins restriction on the messenger RNA contents of bone-matrix proteins,insulin-like growth factor and insulin-like growth factor binding proteins in femur of ovariectomized rats[J].Br J Nutr,1996,75(6):811-823. 被引量:1
  • 2Robb RJ.Conversion of low-affinity interleukin 2 receptors to a high-affinity state following fusion of cell membranes[J].Proc Natl Acad Sci U S A,1986,83(11):3992-3996. 被引量:1
  • 3Boonen S,Mohan S,Dequeker J,et al.Down-regulation of the serum stimulatory components of the insulin-like growth factor (IGF) system (IGF-I,IGF-II,IGF binding protein[BP] -3,and IGFBP-5) in age-related (type II) femoral neck osteoporosis[J].J Bone Miner Res,1999,14(12):2150-2158. 被引量:1

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