摘要
目的:对四个厂家生产的氯化钾缓释片进行pH、时间、释放度的考察,探讨其体外释放机制。方法:按《中国药典》(2010年版)氯化钾缓释片项下"释放度"检查法检测,描绘其三维释放图,对释放度的数据分别以零级,一级,扩散-溶蚀数学模型,Hixson-Crowell方程进行拟合。结果:四个厂家的氯化钾缓释片均以扩散-溶蚀及Hixson-Crowell方程为最佳拟合模型,该模型释放行为基本不受pH影响。结论:四个厂家的氯化钾缓释片的体外释放机制基本相同。
Objective： To study the three dimension （pH-time-release） release characteristics of Potassium Chloride Sus tained Release Tablets from the different factories （A, B, C, D）. Methods： According to Chinese pharmacopoeia Chp （2010） dissolution method. The accumulation release percentage of Potassium Chloride Sustained release Tables under the differ ent pH conditions was determined by measure analysis, then the release characteristics were explored[ by similarity factor method, Zero grade model, First grade model, Diffusion corrosion model and Hixson Crowell model. Results： The release mechanisms （the curves of accumulative release） of the different factories （A, B, C, D） were accorded with the Diffusion corrosion model and Hixson Crowell model. Other, the release behaviors were not affected by pH. Condusion： The four factories of the Diffusion corrosion model and Hixson Crowell model （curves of accumulative release） were same.
出处
《中国医药导报》
CAS
2011年第14期69-71,共3页
China Medical Herald
