摘要
目的探讨高强度聚焦超声(HIFU)联合吉西他滨治疗胰腺癌的临床效果。方法 47例胰腺癌患者随机分为两组:治疗组25例,HIFU联合吉西他滨治疗;对照组22例,单独使用吉西他滨治疗。观察两组临床疗效和临床受益率,并测定治疗前后患者肿瘤标志物CA19-9水平的变化,观察中位生存期和不良反应发生情况。结果治疗组临床疗效和临床受益率均明显高于对照组,差异有统计学意义(P<0.05)。治疗后治疗组CA19-9水平较对照组明显降低,差异有统计学意义(P<0.05)。治疗组中位生存期明显高于对照组,差异有统计学意义(P<0.05)。两组出现骨髓抑制、胃肠道反应、肝功能损伤等不良反应发生率比较,差异均无统计学意义(P>0.05)。结论 HIFU联合吉西他滨有协同作用,可以提高临床疗效,改善患者的生存质量,无严重不良反应发生。
Objective To investigate the clinical effect of high intensity focused ultrasound（HIFU）combined with gemcitabine in treating pancreatic neoplasm.Methods 47 patients with pancreatic neoplasm were randomly divided into two groups：Trial group（25 cases） was treated by HIFU and gemcitabine;Control group（22 cases） was treated by gemcitabine.Therapeutic effect and clinical benefit response（CBR） were observed at the end of the treatment.The levels of CA19-9 were measured before and after therapy in all patients.Median overall survival（MOS） and adverse reaction were also observed.Results The efficacy and CBR of the trial group were significantly higher than those of control group.There were significant differences between the two groups（P0.05）.The levels of CA19-9 in the trial group were significantly reduced compared with those in the control group（P0.05）.MOS of the trial group were significantly higher than that of control group.There were significant differences between the two groups（P0.05）.The differences between the two groups in adverse reactions like marrow suppression,gastrointestinal reaction and hepatic injuries were not statistically significant（P0.05）.Conclusion HIFU combined with gemcitabine for pancreatic neoplasm has synergistic action.It could improve clinical efficacy as well as quality of life,with slight adverse reactions.
出处
《中国全科医学》
CAS
CSCD
北大核心
2011年第14期1597-1599,共3页
Chinese General Practice
关键词
胰腺肿瘤
超声
高强聚焦
经肠
治疗结果
Pancreatic neoplasms
Ultrasound
high-intensity focused
transrectal
Treatment outcome
