摘要
目的:观察前列地尔干乳剂联合甲钴胺胶囊治疗糖尿病周围神经病变的疗效。方法:选择82例糖尿病周围神经病变患者,随机分为试验组(前列地尔+甲钴胺)41例,对照组(甲钴胺)41例,均用门冬胰岛素30特充控制血糖,试验组给予前列地尔干乳剂10μg·d-1+甲钴胺胶囊0.5mg,tid;对照组给予甲钴胺胶囊0.5mg,tid,2组疗程均为3周,观察其对神经传导速度的影响。结果:试验组总有效率为88%,对照组总有效率为54%,2组疗效比较差异有显著性(P<0.01)。试验组对神经传导速度的改善明显优于对照组,2组疗效比较差异有显著性(P<0.01)。2组均未见明显不良反应。结论:前列地尔干乳剂联合甲钴胺胶囊治疗糖尿病神经病变疗效优于单独使用甲钴胺。
OBJECTIVE： To observe the therapeutic efficacy of Alprostadil dry emulsion combined with Mecobalamin capsules in the treatment of diabetes peripheral neuropathy. METHODS： 82 patients with diabetes peripheral neuropathy were randomly assigned to observation group （alprostadil and mecobalamin, 41 case） and control group （mecobalamin, 41 case）. Insulin aspart 30 injection was used to control plasma glucose in 2 groups. Both groups received Mecobalamin capsules 0.5 mg three times a day and observation group were additionally treated with Alprostadil dry emulsion 10 μg·d-1 for three weeks. The therapeutic efficacy and nerve conduction velocity （SNCV, MNCV） of 2 groups were observed. RESULTS： Total effective rate was 88% for observation group and 54% for control group. There was significant difference （P0.01）. The improvement of nerve conduction velocity in observation group was better than control group, there was significant difference between 2 groups （P0.01）. No serious adverse drug reactions were found in 2 groups. CONCLUSION： Alprostadil dry emulsion combined with Mecobalamin capsules is better than mecobalamin alone in the treatment of diabetes peripheral neuropathy.
出处
《中国药房》
CAS
CSCD
北大核心
2011年第20期1895-1896,共2页
China Pharmacy
关键词
前列地尔干乳剂
甲钴胺胶囊
周围神经病变
神经传导速度
Alprostadil dry emulsion
Mecobalamin capsules
Peripheral neuropathies
Nerve conduction velocity
