摘要
目的：观察严重烧伤患者血浆白介素 ８（ＩＬ ８）和ＩＬ １０ 水平的变化，探讨其与烧伤后全身感染的关系。方法：收集１９ 例严重烧伤患者的血浆，利用酶联免疫吸附（ＥＬＩＳＡ）法测定血浆中ＩＬ ８ 和ＩＬ １０ 水平。结果：烧伤后患者血浆ＩＬ ８ 和ＩＬ １０ 水平急剧升高；非脓毒症患者血浆ＩＬ ８ 和ＩＬ １０ 水平在伤后逐渐降至正常，而脓毒症组患者则急剧升高。３ 例死于脓毒症者血浆ＩＬ ８ 和ＩＬ １０ 持续在高水平状态。结论：烧伤能诱导机体产生ＩＬ ８ 和ＩＬ １０；过高的ＩＬ １０
Objective:To observe the changes in plasma interleukin (IL)8 and IL10 levels after burn injury,and the relationship between IL10 levels and development of sepsis.Methods:By using ELISA method,plasma IL8 and IL10 levels were determined in 19 patients with burn injury.Results:IL8 and IL10 levels were significantly increased in burned patients.In patients without sepsis,IL8 and IL10 levels gradually decreased to normal range,and in contrast,they significantly increased in patients with sepsis.Three patients who died from sepsis showed high IL8 and IL10 levels during the period of sepsis.Conclusions:Burn injury could result in production of IL8 and IL10,and elevation of IL10 may be associated with the development of sepsis after burn injury.
出处
《中国危重病急救医学》
CAS
CSCD
1999年第10期594-595,共2页
Chinese Critical Care Medicine
基金
国家自然科学基金
