摘要
对本院48例乳腺癌患者术后肿瘤组织的细胞信号传导通路的人类表皮生长因子受体2（HEPO）、丝氨酸与苏氨酸激酶（Akt）、真核细胞始动因子4E结合蛋白1（4EBP1）、核糖体蛋白S6激酶1（p70S6K1）和核糖体S6行免疫组化染色检测。HER2阳性与阴性表达的肿瘤比较，Akt表达率更高（P〈0．01）。Akt表达的水平与其下游因子4EBP1、p70S6K1的表达呈正相关（P〈0．01，P〈0．05）。4EBP1主要表达在低分化的肿瘤中（P〈0．01），并与肿瘤大小（P〈0．05）、淋巴结的转移（P〈0．01）及局部复发相关（P〈0．01）。提示4EBP1与乳腺癌的肿瘤分级和预后密切相关。
The expression of human epidermal growth factor receptor 2 （HER2）, serine-threonine kinase （Akt）, 4E-binding protein （4EBP1）, phophorylated ribosomal protein S6 kinasel （pTOS6KI） and ribosomal protein S6 （S6） were detected with immunohistoehemistry in 48 cases of human breast cancer. Tumors high-expressing HER2 showed higher Akt expression as compared to tumors with negative HER2 （P 〈 0. 01 ）. Levels of Akt were correlated with the downstream molecules 4EBP1 （ P 〈 0. 01 ） and pTOS6K （ P 〈 0. 05）. 4EBP1 was mainly expressed in poorly differentiated tumors （P 〈0. 01 ） and correlated with tumor size （P 〈 0. 05）, lymph node metastasis （ P 〈 0. 01 ） and locoregional recurrences （ P 〈 0. 01 ）. Results suggest that 4EBP1 may be the main factor in PI-phosphoinositide-3-kinase （PI3K）-Akt-marmnalian targot of rapanycin signal transduetion pathways, which is associated with grade of malignancy and prognosis of breast cancer.
出处
《中华全科医师杂志》
2011年第5期356-358,共3页
Chinese Journal of General Practitioners
关键词
乳腺肿瘤
信号传导
Breast neoplasms
Signal transduction
