摘要
【目的】分析围产期新生儿高胆红素血症（NHB）及其影响因素，为防治NHB提供依据。【方法】回顾分析2005年1月至2007年12月住院1872例新生儿临床资料。记录新生儿的性别、胎次、胎龄、分娩方式、出生时评分、出生体重及头3d胆红素监测情况、合并症、母乳喂养及孕母情况。【结果】引起围产期NHB的危险因素包括剖宫产、母乳缺乏、出生后头3d体重下降、围产窒息、吸入综合征、宫内窘迫、高龄初产、胎龄、感染。其中剖宫产组与非剖宫产组NHB发生率分别为41．0％、33．2％，两组差异有显著性（P〈0．01）；同时剖宫产组合并窒息、呼吸窘迫综合征（RDS）、暂时性呼吸困难（TTN）发生率明显高于非剖宫产组，差异有显著性（P〈O．05）；剖宫产组中母亲有妊娠合并症者NHB发生率为44．0％，略高于母亲无妊娠合并症者NHB发生率（40．2％），两者差异无显著性（P〉0．05）。【结论】剖宫产分娩、母乳缺乏同样要作为NHB围产因素并引起重视，进行早期干预。
[Objective]To analyze the risk factors of perinatal neonatal hyperbilirubinemia（NHB） in order to provide the basis for preventing and treating NHB. [Methods] The clinical data of 1872 neonates in our hospital from January 2005 to December 2007 were analyzed retrospectively. Sex, parity, gestational age, labor mode, Apgar score, birth weight and the changes during first 3 days, bilirubin monitoring, complications, breast-feeding and maternal conditions were recorded. The risk factors of NHB were analyzed by using univariate x2 test and multivariate logistic regression analysis. [Results] The risk factors of prenatal NHB were cesarean section delivery, deficiency of breast feeding, loss of weight in first 3 days after labor, perinatal asphyx- ia, inhalation syndrome, fetal distress, first pregnancy in elder age, gestational age and infection. The incidence of NHB in cesarean section group and non-cesarean section group was 41.0% and 33.2%, respectively, and there was significant difference between two groups（ P 〈0.01）. The incidence of NHB in mothers with pregnancy-induced hypertension in caesarean section group was 44.0%, which was a little higher than that in mothers without pregnancy-induced hypertension（40. 2%）, but there was no significant difference between them（ P 〉0.05）. There were no significant differences in the complications such as asphyxia, hypoxia, HIE, inhalation syndrome, infection and the incidence of NHB between two groups（ P 〉0.05）. [Conclusion] As the risk factors of prenatal NHB, cesarean section delivery and deficiency of breast feeding should be taken into account, and early intervention should be done.
出处
《医学临床研究》
CAS
2011年第4期620-622,625,共4页
Journal of Clinical Research
基金
基金项目广西北海市科技局应用基础研究项目（200305005）
