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肝胆结石片对肥胖大鼠及高胆固醇饲养动物血清胆固醇、胆汁酸的影响

Study on the Hypolipidemic and Weight-reducing Effects of Gandan Jieshi Tablet on Fatty Rats
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摘要 目的:研究肝胆结石片对血脂代谢的影响,为分析制剂的作用、原理提供参考依据。方法:分别采用连续给药、高胆固醇饲豚鼠、高营养肥胖大鼠等模型,观察药物对大鼠体重、血脂及各种肥胖指标的影响。结果:试验表明,连续ig肝胆结石片(卫生部终定名:肝胆消石片)3.0、1.5、0.75g(生药)/(kg.d),连续ig50d对正常大鼠的体重增长率有明显的抑制作用;前两种剂量连续30d,对高胆固醇饲养豚鼠的血清胆固醇的抑制率分别为22.8%、14.6%;总胆汁酸的提高率分别为24.1%、9.2%;对高营养、谷氨酸钠所致肥胖大鼠的体重增长、李氏指数、血清(胆固醇、高密度脂蛋白胆固醇、甘油三酯)、生殖器周围的脂肪重及细胞数均有不同程度的抑制作用。结论:提示肝胆结石片有降血脂及减肥作用。 AIM:To study the effects of Gandan Jieshi Tablets (GJ ) on blood lipid metabolism to provide reference for analysingthe mechanism of the effect of the product. METHODS: To establish animal models of continuously taking medicine, guinea pigsfed on high cholesterol and fatty rats induced by hyperalimentation and to observe the influence of drugs upon body weight, bloodlipid and various obesity indices of rats. RESULTS: GJ orally given in a dose of 1. 5g/ (kg' d), 3 .0g/ (kg' d) for 50 days couldsignificantly decrease body weight of normal rats. The same dose for 30 days could reduce serum cholesterol in 22. 8%, 14. 6% ofguinea--pigs respectively and increase body weight, Li's index, lipid in serum(including cholesterol, PL and TG), weight of fato f perigenitalia and fat cell numbers in fatty rats induced by hyperalimentation and sodium glutanate. CONCLUSION:GJ havehypolipidemic and weight--reducing effects.
出处 《中国药房》 CAS CSCD 1999年第5期206-208,共3页 China Pharmacy
关键词 肝胆结石片 降血脂 减肥 药理 中药 Gandan Jieshi Tablet hypolipidemic effects weight-reducing effects
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