摘要
目的 :观察益胆颗粒防治兔胆结石形成作用及其机制。方法 :通过胆固醇诱发家兔胆结石模型 ,观察益胆颗粒防治胆结石形成作用 ;通过引流家兔胆汁流量的方法 ,观察益胆颗粒的利胆作用 ;采用PcLab生物信号采集处理系统 ,观察益胆颗粒对胆总管肌电和胆压的影响。结果 :益胆颗粒 (5 0 0g·kg-1)可以防治胆固醇诱发家兔结石形成 ,降低兔血清总胆红素与结合胆红素含量。益胆颗粒 (1 2 5、2 5 0及 5 .0 0g·kg-1)促进家兔胆汁引流 ,增加胆汁流量 ;对新斯的明引起oddi括约肌痉挛有明显的缓解作用。结论 :益胆颗粒具有防治胆结石形成作用 ,其机制可能与调节胆红素代谢 ,促进胆汁分泌和缓解Oddi括约肌痉挛有关。
Object:To observe the preventive effect and and discover mechanism of Yingdan keli in treating gallstone in rabbits.Methods:By using gallstone model induced by cholesterol,collecting bile secretion and utilizing PcLab biological signal collecting system,We study the effects of Yingdan keli.Results:Yingdan keli(5 00g·kg -1 ) can inhibit the form of gallstone in rabbits,decrease the contents of T Bil and D Bil inserum;Yingdan keli(1 25、2 50及5.00g·kg -1 ) can increase the bile secre tion of rabbit,relieve the spasm of sphincter of ODDi caused by neosti gmine.Conclusion:Yingdan keli can prevent the form of gallstone,its mechanism might be related to regulating bilirubin metabolism,increasing bile secretion and relieving the spasm of sphincter of ODDi.
出处
《中国中医基础医学杂志》
CAS
CSCD
北大核心
2005年第3期178-179,191,共3页
JOURNAL OF BASIC CHINESE MEDICINE
