摘要
目的探讨无创机械通气治疗老年慢性阻塞性肺疾病(COPD)合并呼吸衰竭的作用。方法将72例60岁以上COPD伴呼吸衰竭患者随机分观察组和对照组,每组各36例,观察组在常规治疗基础上进行无创机械通气治疗,对照组36例患者采用常规治疗,观察并比较两组患者治疗前后呼吸、心率、动脉血气变化情况及临床疗效。结果治疗结束后观察组和对照组有效率分别为80.6%和 44.4%,两组有效率比较差异有统计学意义(χ2=6.887,P<0.05);观察组通气治疗前后pH、动脉氧分压(PaO2) 、动脉二氧化碳分压(PaCO2) 、呼吸、心率等指标明显改善(P< 0.05);治疗48 h 后通气观察组 PaO2 及PaCO2明显好于对照组,P< 0.05。结论经口鼻面罩无创通气治疗老年慢性阻塞性肺疾病并呼吸衰竭,提高 PaO2、SaO2,降低 PaCO2,纠正pH,疗效肯定,简单实用,早期应用可促进疾病康复,是治疗 COPD呼吸衰竭的重要手段,值得临床应用。
Objective To investigate the treatment of non-invasive mechanical ventilation in chronic obstructive pulmonary disease （COPD） combined with respiratory failure. Methods 72 over the age of 60 COPD patients with respiratory failure were randomly divided into treatment group and control group, with 36 patients in each group. On the basis of conventional treatment, non-invasive mechanical ventilation was managed in the treatment group, while conventional therapy was employed in control group. Respiration, heart rate, arterial blood gas and clinical efficacy were observed and compared between two groups before and after treatment. Results After treatment, the efficiency of the treatment group and control group was 80.6% and 44.4% respectively, with statistically significant difference （P0.05）. PH, arterial oxygen pressure （PaO2）, arterial carbon dioxide tension （PaCO2）, breathing and heart rate were significantly improved in treatment group after ventilation （P0.05）; treatment for 48 h waiting ventilation, PaO2 and PaCO2 in treatment group was better than that in the control group （P0.05）. Conclusion The nose and mouth mask ventilation is effective, simple and practical in the treatment of noninvasive chronic obstructive pulmonary disease and respiratory failure, with the increase of PaO2, SaO2, PaCO2, correction of lower pH, promoting disease of early rehabilitation
出处
《海南医学》
CAS
2011年第9期6-8,共3页
Hainan Medical Journal
关键词
慢性阻塞性肺疾病
呼吸衰竭
无创通气
鼻(面)罩
Chronic obstructive pulmonary disease
Respiratory failure
Non-invasive ventilation
Nasal （facial） mask
