摘要
目的：寻找番荔枝科假鹰爪属植物毛叶假鹰爪［ Ｄｅｓｍｏｓ ｄｕ ｍｏｓｕｓ （ Ｒｏｘｂ ．） Ｓａｆｆ］ 根抗肿瘤活性成分。方法：用硅胶柱色谱分离化学成分； Ｕ Ｖ， Ｉ Ｒ， Ｅ Ｉ Ｍ Ｓ，１ Ｈ Ｎ Ｍ Ｒ，１ ３ Ｃ Ｎ Ｍ Ｒ，１ Ｈ１ Ｈ Ｃ Ｏ Ｓ Ｙ， Ｈ Ｍ Ｑ Ｃ， Ｈ Ｍ Ｂ Ｃ， Ｎ Ｏ Ｅ Ｓ Ｙ 等方法鉴定结构。结果：从氯仿萃取物中分离鉴定了６ 个化合物，分别为２甲氧基３甲基４ ，６二羟基５（３′羟基） 肉桂酰基苯甲醛（ Ｉ） ，５羟基７甲氧基８甲酰基３苯甲酰基２ ，６二甲基２ Ｓ，３ Ｒ二氢色原酮（ Ｉ Ｉ） ，豆甾４烯３ ，６二酮（ Ｉ Ｉ Ｉ） ，豆甾烷３ ，６二酮（ Ｉ Ｖ） ，荠宁黄酮（ Ｖ） ，黄芩素７甲醚（ Ｖ Ｉ） 。结论：化合物 Ｉ Ｉ为新化合物，命名为毛叶假鹰爪素 Ａ。 Ｉ， Ｉ Ｉ Ｉ和 Ｉ Ｖ为首次从本种植物中得到。 Ｉ Ｉ Ｉ有细胞毒活性。
AIM: To investigate new compounds with anti tumor activities from the roots of Desmos dumosus of annonaceae. METHODS: The chemical constituents were isolated by silica gel column chromatography, and the structures were elucidated by UV, IR, MS, 1HNMR , 13 CNMR , 1H 1H COSY, HMQC, HMBC and NOESY analysis. RESULTS: Six compounds have been isolated from the CHCl 3 extract of this plant. They were identified as 2 methoxy 3 methyl 4,6 dihydroxy 5(3′ hydroxyl) cinnamoylbenzaldehyde (I), 5 hydroxy 7 methoxy 8 formyl 3 benzoyl 2,6 dimethyl 2S,3R dihydrochromone (II), stigmast 4 ene 3,6 dione (III), stigmastane 3,6 dione (IV), mosloflavone (V) and negletein (VI). CONCLUSION: Compound II, named desmosdumotin A, is a new compound. I, III and IV were found from this plant for the first time. III showed cytotoxic activities.
出处
《药学学报》
CAS
CSCD
北大核心
1999年第9期682-685,共4页
Acta Pharmaceutica Sinica
基金
"九五"军队科研基金
关键词
番荔枝科
毛叶假鹰爪根
中药
化学成分
annonaceae
Desmos lour.
Desmos dumosus
desmosdumotin A
flavonoid
