摘要
研究了桂枝和桂皮醛对环丙沙星在小鼠体内分布的影响,并基于此探讨了桂枝作为引药使用的作用机制.实验中将小鼠分为三组,分别灌胃生理盐水、桂枝（50gkg-1）和桂皮醛（0.25mLkg-1）,然后对三组小鼠尾静脉注射环丙沙星（20mgkg-1）,并以荧光法测定不同时间点小鼠体内各组织中环丙沙星的浓度.结果显示桂枝、桂皮醛均促进了环丙沙星在四肢的分布,桂枝与桂皮醛组相对于生理盐水组可将环丙沙星在四肢的含量提高约40%~200%,证实了桂枝引药到达肢节的作用.桂枝与桂皮醛组对环丙沙星分布情况的影响没有显著性差异,说明桂皮醛很可能是发挥桂枝引药作用的主要物质.
The drug-guide mechanism of Guizhi and its effect on the distribution of ciprofloxacin in mice were investigated in detail. Three groups of mice were administrated with physiological saline, Guizhi （50 g kg？1） and cinnamaldehyde （0.25 mL kg？1）, respectively. Then ciprofloxacin was injected into tail intravenous of the mice. Afterward the concentrations of ciprofloxacin in the mice various tissues were determined by fluorospectrophotometry after different time. The results showed that Guizhi and cinnamaldehyde improved the concentrations of ciprofloxacin in the limbs. Compared to the ＂physiological saline＂ group, the levels of ciprofloxacin increased 40%~200% after administrating Guizhi or cinnamaldehyde. These results confirmed that Guizhi could deliver drug to limbs, and the performance of Guizhi and cinnamaldehyde was very similar. Therefore, it is concluded that cinnamaldehyde is the key substance for Guizhi as drug-guide.
出处
《中国科学：化学》
CAS
CSCD
北大核心
2011年第5期856-862,共7页
SCIENTIA SINICA Chimica
基金
国家自然科学基金(21035005)
西南大学本科生科技创新基金项目(0929001)资助
关键词
桂枝
桂皮醛
引药
环丙沙星
药物分布
荧光分光光度法
Guizhi
cinnamaldehyde
drug-guide
ciprofloxacin
drug distribution
fluorospectrophotometry
