摘要
红曲是以大米为原料,经红曲霉发酵制成的紫红色米曲。在我国已有一千多年药食两用的历史。红曲可有效降低血中胆固醇,因为它含有HMG-CoA还原酶的竞争性抑制剂monacolin K。除了降脂效果以外,红曲还具有降压、降血糖、抗肥胖、防治老年痴呆及骨质疏松等功效。本文综述了近年来红曲的生物活性及药理活性方面的研究,使红曲的药用价值得到进一步的认识,并使红曲的应用前景更广阔。
Red yeast rice （RYR） is produced by the fermentation of rice （Oryza sativa） using Monascus sp., and has a long history as a food colorant and a folk medicine in China. RYR is well-known for lowering blood cholesterol levels due to its bioactive component, monacolin K （lovastatin）. In addition to antihypercholesterolemic effect, RYR showed evidence to be effective for the control of diabetes, hypertension, obesity, as well as for the prevention of Alzheimer＇s disease and osteoporosis. This review is focused on the study of the bioactive and pharmacological effects of RYR.
出处
《中国天然药物》
SCIE
CAS
CSCD
北大核心
2011年第3期161-166,共6页
基金
supported by the National Important Special Foundation of the New Drug Development (No.2008ZX09202-007)~~
关键词
红曲
红曲霉
药理活性
活性成分
Red yeast rice
Monascus
Pharmacological effect
Bioactive component
