摘要
目的观察低分子肝素钠联合低分子右旋糖酐及速尿治疗肾病综合征并急性肾衰竭的疗效。方法将我院2006～2010年312例原发性肾病综合征(PNS)并发29例急性肾衰竭(AFR)的临床患者,随机分为对照组14例及治疗组15例。对照组常规治疗基础上,间歇性输入人体清蛋白后给予速尿静脉滴注,治疗组在常规治疗基础上,给予低分子肝素钠联合低分子右旋糖酐(250ml)及速尿静脉滴注14d。观察两组少尿例数,血液透析例数,尿蛋白,血脂,血尿素氮,血肌酐等指标变化。结果治疗组比对照组在少尿及血液透析例数,血尿素氮,血肌酐等均显著减少(P<0.05);尿蛋白,血脂等无显著变化(P<0.05)。结论低分子肝素钠联合低分子右旋糖酐及速尿治疗肾病综合征并急性肾衰竭疗效确切,优于常规疗法,且经济实用,不良反应小。
Objective To evaluate the clinical efficacy of low molecular weight heparin sodium in combination with low molecular dextran and furosemide treatment of nephrotic syndrome complicating with acute renal failure.Methods 29 patients with acute renal failure came from 312 hospital patients with primary nephrotic syndrome（PNS） from 2006 to 2010 in our hospital were randomly assigned to two treatment groups： the control group（14 cases） and the treatment group（15 cases）.The control group only received intermittent input of human albumin on the basis of conventional therapy and then administered furosemide infusion,but the treatment group received low molecular weight heparin sodium in combination with low molecular dextran and furosemide infusion for 14 days on the basis of conventional therapy.Amount of oliguria and hemodialysis patients were observed.Urinary protein,blood lipids,blood urea nitrogen and serum creatinine were measured both the two groups at the end of the treatment.Results Oliguric patients,hemodialysis patients,blood urea nitrogen,and serum creatinine in the treatment group significantly reduced compare to control group（P0.05）;No significant difference in urinary protein and lipids was found between the two groups（P0.05）.Conclusion Low molecular weight heparin sodium in combination with low molecular dextran and furosemide treatment of nephrotic syndrome complicating with acute renal failure is superior to conventional therapy.It is effective,economical,practical and lower side effects.
出处
《四川医学》
CAS
2011年第4期504-506,共3页
Sichuan Medical Journal
关键词
急性肾衰竭
低分子肝素钠
低分子右旋糖苷
原发性肾病综合征
low molecular weight heparin
low molecular weight dextran
nephrotic syndrome
acute renal failure
